Petrovic T, Bell C
Hypertension. 1986 Feb;8(2):122-7. doi: 10.1161/01.hyp.8.2.122.
The tissue content of norepinephrine, dopamine, and epinephrine was determined in different zones of the kidney in normotensive Sprague-Dawley and Otago Wistar rats and in genetically hypertensive Otago Wistar rats. One kidney in each animal was chronically denervated to allow estimation of the neuronal contribution to renal catecholamine content. In all strains, the renal cortex contained negligible amounts of nonneuronal norepinephrine and dopamine, while outer and inner medullary layers contained progressively larger amounts. Nonneuronal epinephrine was distributed fairly evenly through cortex and medulla. Neuronal norepinephrine content was similar in inner and outer cortex, substantially less in outer medulla, and not discernible in inner medulla. The amounts of neuronal dopamine were consistent with its localization predominantly in noradrenergic nerves. The renal cortices of normotensive Wistar rats contained more neuronal norepinephrine and less neuronal dopamine than those of Sprague-Dawley rats, and the cortices of hypertensive Wistar rats contained slightly more norepinephrine than those of normotensive Wistar rats. In both normotensive strains, long-term salt loading decreased selectively the neuronal norepinephrine in renal cortex. By contrast, in hypertensive animals, cortical norepinephrine was not reduced by salt loading. These results indicate that the genetically hypertensive rat may have an abnormal sympathetic reflex response to increased blood volume.
在正常血压的斯普拉格 - 道利大鼠和奥塔哥威斯塔大鼠以及遗传性高血压的奥塔哥威斯塔大鼠的肾脏不同区域，测定了去甲肾上腺素、多巴胺和肾上腺素的组织含量。对每只动物的一侧肾脏进行长期去神经支配，以评估神经元对肾脏儿茶酚胺含量的贡献。在所有品系中，肾皮质中非神经元性去甲肾上腺素和多巴胺的含量极少，而外髓层和内髓层中的含量则逐渐增加。非神经元性肾上腺素在皮质和髓质中分布较为均匀。神经元性去甲肾上腺素含量在内皮质和外皮质中相似，在外髓质中显著减少，在内髓质中则无法辨别。神经元性多巴胺的含量与其主要定位于去甲肾上腺素能神经一致。正常血压的威斯塔大鼠的肾皮质中神经元性去甲肾上腺素含量比斯普拉格 - 道利大鼠的多，神经元性多巴胺含量比其少，而高血压威斯塔大鼠的皮质中去甲肾上腺素含量比正常血压的威斯塔大鼠略多。在两种正常血压品系中，长期高盐饮食选择性地降低了肾皮质中神经元性去甲肾上腺素的含量。相比之下，在高血压动物中，高盐饮食并未降低皮质去甲肾上腺素的含量。这些结果表明，遗传性高血压大鼠对血容量增加可能具有异常的交感反射反应。
