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联合感染与化疗对豚鼠皮肤利什曼病的保护作用。

Protection of guinea pigs against cutaneous leishmaniasis by combined infection and chemotherapy.

作者信息

El-On J, Witztum A, Schnur L F

出版信息

Infect Immun. 1986 Feb;51(2):704-6. doi: 10.1128/iai.51.2.704-706.1986.

DOI:10.1128/iai.51.2.704-706.1986
PMID:3943909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC262416/
Abstract

A paromomycin and methylbenzethonium chloride ointment cured Leishmania enriettii infections in guinea pigs. Amastigotes were totally eliminated from the treated lesion after 10 days of treatment. A delayed effect also occurred on untreated lesions in the same animals. Lesions treated at various times after infection permitted protective immunity to develop, and 90% of treated animals were refractory to reinfection.

摘要

一种巴龙霉素和氯化甲基苄乙铵软膏治愈了豚鼠的恩氏利什曼原虫感染。治疗10天后，治疗部位的无鞭毛体被完全清除。对同一动物未治疗的病灶也产生了延迟效应。在感染后的不同时间进行治疗的病灶可使保护性免疫得以发展，90%的治疗动物对再次感染具有抵抗力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec8c/262416/71b0558062be/iai00107-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec8c/262416/71b0558062be/iai00107-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec8c/262416/71b0558062be/iai00107-0341-a.jpg

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本文引用的文献

1
Mechanisms of immunity to leishmaniasis. I. Evidence for a changing basis of protection in self-limiting disease.利什曼病免疫机制。I. 自限性疾病中保护基础变化的证据。
Clin Exp Immunol. 1980 Jan;39(1):14-26.
2
Cryosurgery in cutaneous leishmaniasis.皮肤利什曼病的冷冻手术
Br J Dermatol. 1982 Oct;107(4):467-74. doi: 10.1111/j.1365-2133.1982.tb00390.x.
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The present and future of vaccination for cutaneous leishmaniasis.
Prog Clin Biol Res. 1980;47:259-85.
用葡萄糖酸锑钠的非离子表面活性剂囊泡制剂治疗BALB/c小鼠内脏利什曼病所获得的治愈免疫表型不能预防再次感染。
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Development of topical treatment for cutaneous leishmaniasis caused by Leishmania major in experimental animals.实验动物中针对硕大利什曼原虫引起的皮肤利什曼病的局部治疗方法的开发。
Antimicrob Agents Chemother. 1984 Nov;26(5):745-51. doi: 10.1128/AAC.26.5.745.
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Anti-leishmanial activity of immune guinea-pig serum.免疫豚鼠血清的抗利什曼原虫活性。
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Immunological phenomena in leprosy and related diseases.麻风病及相关疾病中的免疫现象。
Adv Immunol. 1971;13:209-66. doi: 10.1016/s0065-2776(08)60185-6.
7
Antibody-induced movement of membrane components of Leishmania enriettii.抗体诱导的恩氏利什曼原虫膜成分运动
J Exp Med. 1974 May 1;139(5):1061-9. doi: 10.1084/jem.139.5.1061.
8
Natural and experimental re-infection of man with Oriental sore.人类东方疖的自然再感染与实验性再感染
Ann Trop Med Parasitol. 1971 Jun;65(2):197-205. doi: 10.1080/00034983.1971.11686746.
9
Immunity in cutaneous leishmaniasis of the guinea-pig.豚鼠皮肤利什曼病的免疫
Clin Exp Immunol. 1970 Sep;7(3):301-41.
10
Problems in leishmaniasis related to immunology.利什曼病中与免疫学相关的问题。
Curr Top Microbiol Immunol. 1969;48:29-42. doi: 10.1007/978-3-642-46163-7_2.