Poulter L W
Clin Exp Immunol. 1980 Jan;39(1):14-26.
Methods of adoptive immunization have been employed to analyse the mechanisms of acquired immunity to leishmanial infection in the guinea pig. It was found that resistance developed 2 weeks after infection and that protection could be passively transferred to normal recipients with short-lived T lymphocytes. Although cells taken from animals at progressive stages of the disease were consistently able to adoptively immunize normal recipients their effectiveness waned from 8 weeks onward. Concomitant serum transfer performed at progressive times during the infection failed to augment the level of immunity generated in normal recipients, and at certain times appeared to have an inhibitory effect on this phenomenon. Serum from convalescent animals however did augment the level of adoptive immunity expressed in recipients. Further experiments revealed that serum taken from recovered animals, 24 hr after re-challenge, was alone capable of transferring immunity to normal recipients. Using immunofluorescent techniques to assay titres of anti-leishmanial antibody, a temporal relationship was found between high antibody titres and the ability of serum to contribute positively to the adoptive immunization of normal recipients. These observations were taken as evidence that the basis of the protective immune response to leishmanial infection may change the course of the disease from a purely cell-mediated mechanism to one involving protective antibody.
已采用过继免疫方法来分析豚鼠对利什曼原虫感染获得性免疫的机制。结果发现，感染后2周产生抵抗力，且保护作用可通过寿命较短的T淋巴细胞被动转移给正常受体。尽管从处于疾病进展阶段的动物身上获取的细胞始终能够对正常受体进行过继免疫，但其效力从8周起逐渐减弱。在感染期间不同时间进行的伴随血清转移未能提高正常受体产生的免疫水平，且在某些时候似乎对这一现象有抑制作用。然而，恢复期动物的血清确实提高了受体中过继免疫的水平。进一步的实验表明，再次攻击后24小时从康复动物身上采集的血清 alone 能够将免疫力转移给正常受体。使用免疫荧光技术检测抗利什曼原虫抗体滴度，发现高抗体滴度与血清对正常受体过继免疫产生积极作用的能力之间存在时间关系。这些观察结果被视为证据，表明对利什曼原虫感染的保护性免疫反应基础可能将疾病进程从单纯的细胞介导机制转变为涉及保护性抗体的机制。
原文中“alone”翻译时位置有误，正确译文应是“进一步的实验表明，再次攻击后24小时从康复动物身上采集的血清能够单独将免疫力转移给正常受体。” 。 整体译文基于纠正后的内容。
