JØrgensen Torben, Jacobsen Rikke K, Weinreich Petersen Marie, Bjerregaard Anne A, Ulfbeck Schovsbo Signe, Gormsen Lise K, Falgaard Eplov Lene, Linneberg Allan, Fink Per, Eriksen Benros Michael, Dantoft Thomas
Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Department of Public Health, Faculty of Health and Medical Science, University of Copenhagen, Denmark.
Scand J Public Health. 2024 Oct 22:14034948241283545. doi: 10.1177/14034948241283545.
To assess whether lifestyle factors, including sleep pattern, are predictors for the development of functional somatic disorder (FSD).
A population-based prospective cohort of 9656 men and women aged 18-76 years was established in 2011-2015 and invited for re-examination in 2017-2020, when 5738 participated. Median follow-up period was 65 months. Participants filled in validated questionnaires on lifestyle, sleep pattern and various delimitations of FSD, which were operationalized using two different approaches: bodily distress syndrome (BDS) and functional somatic syndromes (FSS) (i.e. chronic fatigue, chronic widespread pain (CWP), irritable bowel, and multiple chemical sensitivity (MCS)). Baseline lifestyle and sleep pattern in relation to incidence of BDS and FSS (chronic fatigue, CWP, irritable bowel, MCS) was analysed by logistic regressions, adjusted for age, sex and subjective social status.
Inferior sleep quality at baseline predicted both incidence of BDS and all FSS delimitations except MCS. Smoking, alcohol intake, and low physical activity, but not diet, were predictors for the development of BDS. No uniform pattern was observed for the FSS. Smoking predicted development of chronic fatigue, CWP and irritable bowel, but not MCS. Alcohol and food quality only influenced the development of chronic fatigue whereas low physical activity only influenced the development of chronic fatigue and CWP.
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评估包括睡眠模式在内的生活方式因素是否为功能性躯体障碍（FSD）发生的预测因素。
在2011 - 2015年建立了一个基于人群的前瞻性队列，纳入9656名年龄在18 - 76岁的男性和女性，并于2017 - 2020年邀请他们进行重新检查，其中5738人参与。中位随访期为65个月。参与者填写了关于生活方式、睡眠模式和FSD各种界定的有效问卷，这些问卷使用两种不同方法进行操作化：身体不适综合征（BDS）和功能性躯体综合征（FSS）（即慢性疲劳、慢性广泛性疼痛（CWP）、肠易激综合征和多重化学敏感性（MCS））。通过逻辑回归分析基线生活方式和睡眠模式与BDS和FSS（慢性疲劳、CWP、肠易激综合征、MCS）发病率的关系，并对年龄、性别和主观社会地位进行了调整。
基线时较差的睡眠质量可预测BDS的发病率以及除MCS外所有FSS界定的发病率。吸烟、饮酒和低体力活动是BDS发生的预测因素，但饮食不是。FSS未观察到统一模式。吸烟可预测慢性疲劳、CWP和肠易激综合征的发生，但不能预测MCS。酒精和食物质量仅影响慢性疲劳的发生，而低体力活动仅影响慢性疲劳和CWP的发生。
