Abodollahi Samira, Poorbahri Ghesmat Shamimeh, Khoshnam Rad Mahsa, Behrouzi Kamran
Department of Obstetrics and Gynaecology, Alborz University of Medical Sciences, Alborz, Iran.
Cardiovascular Research Center, Alborz University of Medical Sciences, Alborz, Iran.
J Family Reprod Health. 2024 Sep;18(3):160-163. doi: 10.18502/jfrh.v18i3.16657.
Oxytocin is commonly used during labor and delivery for induction of labor and prevention of postpartum hemorrhage. While previous studies have explored the effects of labor oxytocin use on maternal and neonatal outcomes, there is a paucity of research on its impact on newborn liver enzyme function. This study aimed to assess the effects of labor oxytocin use on liver enzyme function in newborns.
A case-control study was conducted. The case group consisted of 70 newborns whose mothers received oxytocin during labor, while the control group consisted of 70 newborns whose mothers did not receive oxytocin. Complete blood count (CBC), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total and indirect bilirubin levels were measured in all newborns on the second day of life.
The levels of AST and total and indirect bilirubin were found to be higher in the case group than in the control group (51 vs. 42, 7.8 vs. 4.6, and 7.4 vs. 4, respectively; p < 0.005). The levels of CPK and LDH were also higher in the case group (p < 0.005). However, the difference in ALT levels was not significant between the study groups.
The observed increase in liver enzymes in this study can indicate the effect of maternal oxytocin on the newborn's liver function. While the changes in liver enzyme levels due to oxytocin use were not found to be high enough to cause liver damage, the increase in CPK and LDH levels could potentially elevate bilirubin levels due to hemolysis. Further research is needed to confirm these findings and explore the underlying mechanisms.
催产素在分娩过程中常用于引产和预防产后出血。虽然此前的研究探讨了分娩时使用催产素对母婴结局的影响，但关于其对新生儿肝脏酶功能影响的研究却很少。本研究旨在评估分娩时使用催产素对新生儿肝脏酶功能的影响。
进行了一项病例对照研究。病例组由70名母亲在分娩时接受催产素的新生儿组成，而对照组由70名母亲未接受催产素的新生儿组成。在所有新生儿出生后第二天测量全血细胞计数（CBC）、乳酸脱氢酶（LDH）、肌酸磷酸激酶（CPK）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）以及总胆红素和间接胆红素水平。
发现病例组的AST、总胆红素和间接胆红素水平高于对照组（分别为51对42、7.8对4.6和7.4对4；p<0.005）。病例组的CPK和LDH水平也较高（p<0.005）。然而，研究组之间ALT水平的差异不显著。
本研究中观察到的肝脏酶升高可能表明母亲使用催产素对新生儿肝功能的影响。虽然未发现因使用催产素导致的肝酶水平变化高到足以引起肝损伤，但CPK和LDH水平的升高可能因溶血而潜在地升高胆红素水平。需要进一步研究来证实这些发现并探索潜在机制。
