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微量营养素与雄激素性脱发:系统评价。

Micronutrients and Androgenetic Alopecia: A Systematic Review.

机构信息

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

出版信息

Mol Nutr Food Res. 2024 Nov;68(22):e2400652. doi: 10.1002/mnfr.202400652. Epub 2024 Oct 23.

Abstract

SCOPE

Hair loss is a common problem that can negatively impact individuals' psychological well-being. Androgenetic alopecia (AGA) is one of the most prevalent types of nonscarring hair loss. This review summarizes the existing evidence on the relationship between AGA and various micronutrients, including vitamin B, vitamin D, vitamin A, vitamin C, iron, selenium, zinc, manganese, and copper.

METHODS

A literature search was conducted to identify relevant articles published between 1993 and 2023. The search identified 49 relevant articles.

RESULTS

The findings suggest that deficiencies or imbalances in these micronutrients may contribute to the pathogenesis of AGA and represent modifiable risk factors for hair loss prevention and treatment. Vitamin B, vitamin D, iron, and zinc appear to play critical roles in hair growth and maintenance. Deficiencies in these micronutrients have been associated with increased risk of AGA, while supplementation with these nutrients has shown potential benefits in improving hair growth and preventing hair loss. However, the current evidence is not entirely consistent, with some studies reporting no significant associations.

CONCLUSION

Deficiencies or imbalances in specific vitamins and minerals, especially vitamin B, vitamin D, Fe, Se, and Zn are involved in the pathogenesis of AGA and may represent modifiable risk factors for the treatment and prevention of this condition.

摘要

范围

脱发是一个常见的问题,可能会对个人的心理健康产生负面影响。雄激素性脱发(AGA)是最常见的非瘢痕性脱发类型之一。本综述总结了 AGA 与各种微量营养素之间关系的现有证据,包括维生素 B、维生素 D、维生素 A、维生素 C、铁、硒、锌、锰和铜。

方法

进行了文献检索,以确定 1993 年至 2023 年期间发表的相关文章。检索确定了 49 篇相关文章。

结果

研究结果表明,这些微量营养素的缺乏或失衡可能导致 AGA 的发病机制,并代表脱发预防和治疗的可改变的危险因素。维生素 B、维生素 D、铁和锌似乎在毛发生长和维持中发挥关键作用。这些微量营养素的缺乏与 AGA 的风险增加有关,而这些营养素的补充已显示出改善毛发生长和预防脱发的潜力。然而,目前的证据并不完全一致,一些研究报告没有发现显著的相关性。

结论

特定维生素和矿物质(尤其是维生素 B、维生素 D、Fe、Se 和 Zn)的缺乏或失衡与 AGA 的发病机制有关,可能代表这种疾病治疗和预防的可改变的危险因素。

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