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基于水凝胶的栓塞剂的进展：按治疗机制分类。

Advancements in hydrogel-based embolic agents: Categorized by therapeutic mechanisms.

机构信息

Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

出版信息

Cancer Med. 2024 Oct;13(20):e70183. doi: 10.1002/cam4.70183.

DOI:10.1002/cam4.70183
PMID:39440706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11497111/
Abstract

BACKGROUND

Transcatheter arterial embolization (TAE) is a crucial technique in interventional radiology. Hydrogel-based embolic agents show promise due to their phase transition and drug-loading capabilities. However, existing categorizations of these agents are confusing.

AIMS

This review tackles the challenge of categorizing hydrogel-based embolic agents based on their therapeutic mechanisms, including transportation, accumulation, interaction, and elimination. It also addresses current challenges and controversies in the field while highlighting future directions for hydrogel-based embolicagents.

MATERIALS AND METHODS

We conducted a systematic review of papers published in PUBMED from 2004 to 2024, focusing primarily on preclinical trials.

RESULTS

Various kinds of hydrogel embolic agents were introduced according to their therapeutic mechanisms.

DISCUSSION

Most hydrogel embolic agents were specifically designed for effective accumulation and interaction. Recent advancement highlight the potential of multifunctional hydrogel embolic agents.

CONCLUSION

This new categorizations provided valuable insights into hydrogel embolic agents, potentially guiding material scientists and interventional radiologists in the development of novel hydrogel embolic agents in transarterial embolization.

摘要

背景

经导管动脉栓塞术（TAE）是介入放射学中的一项关键技术。基于水凝胶的栓塞剂因其相变和载药能力而显示出前景。然而，这些制剂的现有分类令人困惑。

目的

本综述针对基于治疗机制对水凝胶栓塞剂进行分类的挑战，包括运输、积累、相互作用和消除。它还解决了该领域当前的挑战和争议，同时强调了水凝胶栓塞剂的未来方向。

材料和方法

我们对 2004 年至 2024 年在 PUBMED 上发表的论文进行了系统回顾，主要侧重于临床前试验。

结果

根据治疗机制介绍了各种类型的水凝胶栓塞剂。

讨论

大多数水凝胶栓塞剂是专门设计用于有效积累和相互作用的。最近的进展突出了多功能水凝胶栓塞剂的潜力。

结论

这种新的分类为水凝胶栓塞剂提供了有价值的见解，可能指导材料科学家和介入放射学家在经动脉栓塞中开发新型水凝胶栓塞剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/849f0875c84b/CAM4-13-e70183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/efde024341af/CAM4-13-e70183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/3e3103396b0f/CAM4-13-e70183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/cd57af2f9845/CAM4-13-e70183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/638b0798440f/CAM4-13-e70183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/849f0875c84b/CAM4-13-e70183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/efde024341af/CAM4-13-e70183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/3e3103396b0f/CAM4-13-e70183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/cd57af2f9845/CAM4-13-e70183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/638b0798440f/CAM4-13-e70183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b82/11497111/849f0875c84b/CAM4-13-e70183-g006.jpg

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