Kankva Divyesh, Prajapati Parixit, Elossaily Gehan M, Prajapati Bhupendra
SSR College of Pharmacy, Sayli, Silvassa, 396230, Union Territory of Dadra and Nagar Haveli and Daman and Diu, India.
Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh11597, Saudi Arabia.
Curr Med Chem. 2024 Oct 21. doi: 10.2174/0109298673328126241003092124.
Cyclodextrin Metal-Organic Frameworks (CD MOFs) represent an innovative class of materials with remarkable properties and a broad range of applications. This review provides a comprehensive overview of the synthesis techniques, structural characterization, and diverse applications of CD-MOFs. By combining cyclodextrins (CDs) with metal-organic frameworks (MOFs), CD-MOFs are developed with enhanced functionality. The synthesis methods, including various metal sources, coordination modes, and post-synthesis modifications, are discussed alongside advanced structural characterization techniques like X-ray crystallography and spectroscopic methods. The unique characteristics of CD-MOFs, such as high specific surface area, tunable porosity, and customizable chemical structure, make them exceptional candidates for applications in gas adsorption, drug delivery, catalysis, sensing, and environmental remediation. Notably, CD-MOFs show significant promise as nanocarriers in drug delivery systems, offering improved therapeutic outcomes due to their efficient encapsulation and controlled release capabilities. The review highlights recent advancements and underscores the potential impact of CD-MOFs in driving future innovations across various scientific fields.
环糊精金属有机框架材料（CD-MOFs）是一类具有卓越性能和广泛应用的创新材料。本综述全面概述了CD-MOFs的合成技术、结构表征及多样应用。通过将环糊精（CDs）与金属有机框架（MOFs）相结合，开发出了功能增强的CD-MOFs。文中讨论了合成方法，包括各种金属源、配位模式以及合成后修饰，同时还介绍了诸如X射线晶体学和光谱学方法等先进的结构表征技术。CD-MOFs的独特特性，如高比表面积、可调孔隙率和可定制化学结构，使其成为气体吸附、药物递送、催化、传感和环境修复等应用的优异候选材料。值得注意的是，CD-MOFs在药物递送系统中作为纳米载体显示出巨大潜力，因其高效的包封和控释能力而能提供更好的治疗效果。本综述突出了近期进展，并强调了CD-MOFs在推动各科学领域未来创新方面的潜在影响。
