Sá Ana Carolina Micheletti Gomide Nogueira de, Bacal Nydia Strachman, Gomes Crizian Saar, Silva Tércia Moreira Ribeiro da, Gonçalves Renata Patrícia Fonseca, Malta Deborah Carvalho
Universidade Federal de Minas Gerais, School of Nursing, Graduate Program in Nursing - Belo Horizonte (MG), Brazil.
Centro de Hematologia de São Paulo. Clinical Pathology, Flow Cytometry sector Hospital Israelita Albert Einstein - São Paulo (SP), Brazil.
Rev Bras Epidemiol. 2023 Apr 21;26Suppl 1(Suppl 1):e230004. doi: 10.1590/1980-549720230004.supl.1. eCollection 2023.
To estimate the reference intervals (RIs) of complete blood count parameters in the Brazilian adult population.
Cross-sectional study, with data from the National Health Survey (Pesquisa Nacional de Saúde - PNS), between 2014-2015. The final sample consisted of 2,803 adults. To establish the RIs, exclusion criteria were applied, outliers were removed and partitions were made by gender, age, and race/skin color. The non-parametric method was adopted. Differences were assessed using the Mann Whitney and Kruskal Wallis tests (p≤0.05).
There were statistically significant differences for the following hematological parameters based on gender, red blood cells, hemoglobin, hematocrit, MCH, MCHC, eosinophils and absolute monocytes, neutrophils and platelets (p≤0.05). When analyzed by age, the RIs were statistically different in females for hematocrit, MCV, white blood cells and RDW and in males for red blood cells, white blood cells, eosinophils, mean platelet volume, MCV, RDW, and MCH (p≤0.05). For race/color, there were differences in the RIs for parameters of hemoglobin, MCH, MCHC, white blood cells and mean platelet volume, neutrophils and absolute eosinophils (p≤0.05).
The differences found in the RIs of some in blood count parameters in Brazilian adults reaffirm the importance of having their own laboratory reference standards. The results can support a more accurate interpretation of tests, adequate identification and disease prevention in Brazil.
评估巴西成年人群全血细胞计数参数的参考区间（RIs）。
采用横断面研究，数据来源于2014 - 2015年的全国健康调查（Pesquisa Nacional de Saúde - PNS）。最终样本包括2803名成年人。为确定参考区间，应用了排除标准，去除了异常值，并按性别、年龄和种族/肤色进行了划分。采用非参数方法。使用Mann Whitney和Kruskal Wallis检验评估差异（p≤0.05）。
基于性别，以下血液学参数存在统计学显著差异：红细胞、血红蛋白、血细胞比容、平均红细胞血红蛋白含量（MCH）、平均红细胞血红蛋白浓度（MCHC）、嗜酸性粒细胞和绝对单核细胞、中性粒细胞和血小板（p≤0.05）。按年龄分析时，女性的血细胞比容、平均红细胞体积（MCV）、白细胞和红细胞分布宽度（RDW）以及男性的红细胞、白细胞、嗜酸性粒细胞、平均血小板体积、MCV、RDW和MCH的参考区间存在统计学差异（p≤0.05）。对于种族/肤色，血红蛋白、MCH、MCHC、白细胞和平均血小板体积、中性粒细胞和绝对嗜酸性粒细胞的参数参考区间存在差异（p≤0.05）。
巴西成年人血细胞计数参数参考区间中发现的差异再次证实了拥有自身实验室参考标准的重要性。这些结果有助于在巴西更准确地解读检测结果、进行充分的疾病识别和预防。
