Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee.
Medavera, Inc, Springfield, Missouri.
J Infect Dis. 2024 Oct 23;230(Supplement_3):S190-S196. doi: 10.1093/infdis/jiae416.
Pharyngitis is an inflammatory condition of the pharynx and/or tonsils commonly seen in both children and adults. Viruses and bacteria represent the most common encountered etiologic agents-yeast/fungi and parasites are infrequently implicated. Some of these are predominantly observed in unique populations (eg, immunocompromised or unvaccinated individuals). This manuscript (part 3 of 3) summarizes the current state of biomarker diagnostic testing and highlights the expanding role they will likely play in the expedited diagnosis and management of patients with acute pharyngitis. Biomarkers, in conjunction with rapid antigen and/or nucleic acid amplification testing, will likely become the standard of care to accurately diagnose the etiologic agent(s) of pharyngitis. This novel testing paradigm has the potential to guide appropriate patient management and antibiotic stewardship by accurately determining if the cause of pharyngitis is due to a viral or bacterial etiology.
咽炎是一种常见于儿童和成人的咽部和/或扁桃体炎症。病毒和细菌是最常见的病因，而酵母/真菌和寄生虫则很少涉及。其中一些主要见于特定人群（例如，免疫功能低下或未接种疫苗的个体）。本手稿（共 3 部分）总结了目前生物标志物诊断检测的现状，并强调了它们在加速急性咽炎患者诊断和治疗方面可能发挥的作用。生物标志物与快速抗原和/或核酸扩增检测相结合，可能成为准确诊断咽炎病因的标准。这种新的检测模式有可能通过准确确定咽炎的病因是病毒还是细菌，从而指导患者的适当管理和抗生素管理。
