膦甲酸滴眼液治疗难治性单纯疱疹性角膜炎。
Foscarnet eyedrops for the treatment of refractory herpetic keratitis.
作者信息
Awh Caroline C, Knapp Austen N, Goshe Jeffrey M, See Craig W, Lowder Careen Y
机构信息
Cole Eye Institute, Cleveland Clinic, i-32, 9500, Euclid Ave, Cleveland, OH, 44195, USA.
出版信息
J Ophthalmic Inflamm Infect. 2024 Oct 23;14(1):54. doi: 10.1186/s12348-024-00395-0.
PURPOSE
The purpose of this case series is to describe the clinical course of patients receiving foscarnet eyedrops for the treatment of refractory herpetic keratitis.
OBSERVATIONS
Six patients diagnosed with herpetic keratitis were treated with foscarnet 24 mg/mL (2.4%) eyedrops with resulting improvement in keratitis.
CONCLUSION
Topical foscarnet may be a safe and effective treatment for herpetic keratitis in conjunction with, or as an alternative to, conventional antiviral therapy. This is an off-label use of foscarnet.
目的
本病例系列的目的是描述接受膦甲酸钠滴眼液治疗难治性疱疹性角膜炎患者的临床病程。
观察结果
6例诊断为疱疹性角膜炎的患者接受了24mg/mL（2.4%）膦甲酸钠滴眼液治疗，角膜炎症状得到改善。
结论
局部使用膦甲酸钠可能是一种安全有效的治疗疱疹性角膜炎的方法，可与传统抗病毒疗法联合使用或作为替代疗法。这是膦甲酸钠的一种非标签用途。
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