Cahuapaza-Gutierrez Nelson Luis
Facultad de Ciencias de La Salud, Carrera de Medicina Humana, Universidad Científica del Sur, Lima, Perú.
CHANGE Research Working Group, Universidad Científica del Sur, Lima, Perú.
Ann Hematol. 2024 Dec;103(12):4989-5005. doi: 10.1007/s00277-024-06052-9. Epub 2024 Oct 23.
Patients infected with SARS-CoV-2 and vaccinated against COVID-19 could develop aplastic anemia (AA). Comprehensive review and analysis were conducted through a selective literature search in PubMed, Scopus, EMBASE, and Web of Science. For this analysis, 26 studies were included, comprising 16 case reports, 7 case series, and 3 observational studies, totaling 53 patients. The causes of acquired or idiopathic AA are diverse; this review presents recent findings, including possible new etiologies such as SARS-CoV-2 infection and COVID-19 vaccines. This possible association is explored, addressing the existing gap, and aiming to improve daily medical practice. This article reviews the relationship between AA and SARS-CoV-2 infection, as well as COVID-19 vaccines, analyzing cases of de novo occurrence and relapses of AA. Although a definitive mechanistic link has not yet been established, possible underlying pathophysiological mechanisms are explored.
感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）并接种了新型冠状病毒肺炎（COVID-19）疫苗的患者可能会发生再生障碍性贫血（AA）。通过在PubMed、Scopus、EMBASE和Web of Science中进行选择性文献检索，开展了全面的综述和分析。本次分析纳入了26项研究，包括16例病例报告、7个病例系列和3项观察性研究，共计53例患者。获得性或特发性AA的病因多种多样；本综述介绍了近期的研究结果，包括SARS-CoV-2感染和COVID-19疫苗等可能的新病因。探讨了这种可能的关联，填补现有空白，旨在改善日常医疗实践。本文综述了AA与SARS-CoV-2感染以及COVID-19疫苗之间的关系，分析了AA新发和复发的病例。尽管尚未建立明确的机制联系，但探讨了可能的潜在病理生理机制。
