Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
S. N. Fyodorov Federal State Institution National Medical Research Center Intersectoral Research and Technology Complex "Eye Microsurgery" Ministry of Health of the Russian Federation, Novosibirsk Branch, Novosibirsk, Russia.
Bull Exp Biol Med. 2024 Oct;177(6):774-779. doi: 10.1007/s10517-024-06266-x. Epub 2024 Oct 23.
The expression of markers associated with epithelial-mesenchymal transition (EMT) and extracellular matrix degradation in human uveal melanoma tissue samples and postequatorial zone of the choroid was assessed by immunohistochemical staining. Increased expression of EMT markers E-cadherin and vimentin was observed in the tumor. The ratio of MMP-9 to TIMP-1 proteins related to the extracellular matrix degradation was higher in the tumor. These results may indicate activation of EMT-like process in the uveal melanoma cells and degradation of the extracellular matrix, which can contribute to the development of collective invasion in uveal melanoma.
通过免疫组织化学染色评估了人眼葡萄膜黑色素瘤组织样本和后赤道区中与上皮-间充质转化（EMT）和细胞外基质降解相关的标志物的表达。在肿瘤中观察到 EMT 标志物 E-钙黏蛋白和波形蛋白的表达增加。与细胞外基质降解相关的 MMP-9 与 TIMP-1 蛋白的比率在肿瘤中更高。这些结果可能表明葡萄膜黑色素瘤细胞中 EMT 样过程的激活和细胞外基质的降解，这有助于葡萄膜黑色素瘤的集体浸润的发展。
