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褪黑素纳米粒给药可改善夏季热应激下未成年奥希姆公羊的睾丸血流、睾丸实质的回声质地、阴囊周长以及雌二醇和一氧化氮水平。

Administration of melatonin nanoparticles improves testicular blood flow, echotexture of testicular parenchyma, scrotal circumference, and levels of estradiol and nitric oxide in prepubertal ossimi rams under summer heat stress.

机构信息

Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

出版信息

Vet Res Commun. 2024 Dec;48(6):3953-3965. doi: 10.1007/s11259-024-10563-1. Epub 2024 Oct 23.

DOI:10.1007/s11259-024-10563-1
PMID:39441486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11538174/
Abstract

Environmental heat stress (HS) impairs reproductive efficiency in farm animals. This study investigated, for the first time, how the melatonin and melatonin nanoparticles treatment affected the testicular hemodynamics, testicular volume, echotexture [Pixel intensity (PIX) and integrated density (IND)], scrotal circumference, serum concentration of testosterone (T), estradiol (E), nitric oxide (NO), and total antioxidant capacity (TAC) in prepubertal Ossimi ram lambs in hot climatic conditions. The lambs undergoing examination had a temperature humidity index (THI) of 87.05 ± 1.70, indicating severe HS condition. Fifteen prepubertal Ossimi ram lambs were exposed to a single s.c injection of either nano melatonin (nano melatonin group; 20 mg/ram; n 5) or melatonin suspended in two ml of corn oil (melatonin group; 40 mg/ram; n 5) or two ml of corn oil (control group; n 5). Blood collection and ultrasonographic assessment of the testes and supratesticular arteries (STAs) were conducted immediately before treatment (W0) and once weekly for six successive weeks after nano melatonin and melatonin injection (W1-W6). Results revealed decreases (P < 0.05) in the Doppler indices (resistive index; RI and pulsatility index; PI) of the testicular arteries at most time points of the study in the nano melatonin and melatonin groups. PIX of testicular parenchyma was significantly increased (P ˂ 0.05) in the treated groups compared to the control one. IND of testicular parenchyma increased significantly in the nano melatonin group compared to the melatonin and control groups. Testicular volume and scrotal circumference significantly increased (P < 0.05) in nano melatonin and melatonin groups compared to the control one. T concentration did not significantly (P > 0.05) change in the treated groups compared to the control group. E, NO, and TAC concentrations increased (P < 0.05) in the treated groups compared to the control one. In conclusion, this study extrapolated that administrations of melatonin or nano melatonin can ameliorate the effects of environmental HS in prepubertal Ossimi ram lambs with a more protective effect and lower dose of nano melatonin.

摘要

环境热应激（HS）会损害农场动物的繁殖效率。本研究首次探讨了褪黑素和褪黑素纳米粒子治疗如何影响睾丸血液动力学、睾丸体积、回声纹理[像素强度（PIX）和积分密度（IND）]、阴囊周长、血清中睾丸激素（T）、雌二醇（E）、一氧化氮（NO）和总抗氧化能力（TAC）浓度在炎热气候条件下的未成年 Ossimi 公羊。接受检查的羔羊的温度湿度指数（THI）为 87.05±1.70，表明处于严重的 HS 状态。15 只未成年 Ossimi 公羊接受了单次皮下注射，要么是纳米褪黑素（纳米褪黑素组；20mg/ram；n=5），要么是悬浮在 2ml 玉米油中的褪黑素（褪黑素组；40mg/ram；n=5），要么是 2ml 玉米油（对照组；n=5）。在治疗前（W0）和纳米褪黑素和褪黑素注射后每周一次连续 6 周（W1-W6）进行血液采集和睾丸和精索外动脉（STA）的超声评估。结果表明，在研究的大多数时间点，纳米褪黑素和褪黑素组睾丸动脉的多普勒指数（阻力指数；RI 和搏动指数；PI）均降低（P<0.05）。与对照组相比，治疗组睾丸实质的 PIX 显著增加（P<0.05）。与褪黑素组和对照组相比，纳米褪黑素组睾丸实质的 IND 显著增加。与对照组相比，纳米褪黑素和褪黑素组的睾丸体积和阴囊周长显著增加（P<0.05）。与对照组相比，治疗组的 T 浓度没有显著变化（P>0.05）。与对照组相比，治疗组的 E、NO 和 TAC 浓度增加（P<0.05）。综上所述，本研究推断，褪黑素或纳米褪黑素的给药可以改善未成年 Ossimi 公羊在环境 HS 下的影响，纳米褪黑素的保护作用更强，剂量更低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/0dbcee1e6ada/11259_2024_10563_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/25ce26120f7a/11259_2024_10563_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/ea85181da208/11259_2024_10563_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/2f2badd808f8/11259_2024_10563_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/e4b8dd9b81da/11259_2024_10563_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/6e64b2aadbb3/11259_2024_10563_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/be4c50a7ca12/11259_2024_10563_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/0dbcee1e6ada/11259_2024_10563_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/25ce26120f7a/11259_2024_10563_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/ea85181da208/11259_2024_10563_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/2f2badd808f8/11259_2024_10563_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/e4b8dd9b81da/11259_2024_10563_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/6e64b2aadbb3/11259_2024_10563_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/be4c50a7ca12/11259_2024_10563_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdae/11538174/0dbcee1e6ada/11259_2024_10563_Fig7_HTML.jpg

相似文献

[1]
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Vet Res Commun. 2024-12

[2]
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[3]
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[6]
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[7]
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[8]
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引用本文的文献

[1]
Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management.

Vet Med Sci. 2025-9

[2]
Melatonin Improves Semen Quality by Modulating Oxidative Stress, Endocrine Hormones, and Tryptophan Metabolism of Hu Rams Under Summer Heat Stress and the Non-Reproductive Season.

Antioxidants (Basel). 2025-5-24

本文引用的文献

[1]
Spatial local expressions of kisspeptin in the uterus and uterine tubes and its relationship to the reproductive potential in goats.

Domest Anim Endocrinol. 2024-7

[2]
Melatonin Administration Enhances Testicular Volume, Testicular Blood Flow, Semen Parameters and Antioxidant Status during the Non-Breeding Season in Bafra Rams.

Animals (Basel). 2024-1-29

[3]
Evaluation of the effect of melatonin implantation in rams and eCG dose in ewes synchronized by a CIDR-eCG protocol on reproductive performance of Lacaune sheep breed during non-breeding season.

Anim Reprod Sci. 2023-12

[4]
Does Size Matter? Testicular Volume and Its Predictive Ability of Sperm Production in Rams.

Animals (Basel). 2023-10-13

[5]
Application of ultrasound technique to evaluate the testicular function and its correlation to the sperm quality after different collection frequency in rams.

Front Vet Sci. 2022-11-25

[6]
Intramuscular administration of l-arginine boosts testicular hemodynamics, plasma concentrations of testosterone and nitric oxide in heat-stressed rams.

Theriogenology. 2023-2

[7]
Effects of melatonin administration on testicular hemodynamics, echotexture, steroids production, and semen parameters during the non-breeding season in Ossimi rams.

Theriogenology. 2022-5

[8]
Nanotechnology-based advances in the efficient delivery of melatonin.

Cancer Cell Int. 2022-1-29

[9]
Ageing affects plasma steroid concentrations and testicular volume, echotexture and haemodynamics in rams.

Andrologia. 2022-2

[10]
Melatonin improves testicular haemodynamics, echotexture and testosterone production in Ossimi rams during the breeding season.

Reprod Domest Anim. 2021-11

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