Mirza-Aghazadeh-Attari Mohammad, Mihanfar Ainaz, Yousefi Bahman, Majidinia Maryam
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Cancer Cell Int. 2022 Jan 29;22(1):43. doi: 10.1186/s12935-022-02472-7.
N-[2-(5-methoxy-1H-indol-3-yl) ethyl] or simply melatonin is a biogenic amine produced by pineal gland and recently recognized various other organs. Because of a broad range of biological function melatonin is considered as a therapeutic agent with high efficacy in the treatment of multiple disorders, such as cancer, degenerative disorders and immune disease. However, since melatonin can affect receptors on the cellular membrane, in the nucleus and can act as an anti-oxidant molecule, some unwanted effects may be observed after administration. Therefore, the entrapment of melatonin in biocompatible, biodegradable and safe nano-delivery systems can prevent its degradation in circulation; decrease its toxicity with increased half-life, enhanced pharmacokinetic profile leading to improved patient compliance. Because of this, nanoparticles have been used to deliver melatonin in multiple studies, and the present article aims to cumulatively illustrate their findings.
N-[2-(5-甲氧基-1H-吲哚-3-基)乙基]，即褪黑素，是一种由松果体产生的生物胺，最近在其他各种器官中也被发现。由于褪黑素具有广泛的生物学功能，它被认为是一种在治疗多种疾病（如癌症、退行性疾病和免疫疾病）方面具有高效性的治疗剂。然而，由于褪黑素可以影响细胞膜上和细胞核中的受体，并能作为一种抗氧化分子，给药后可能会观察到一些不良影响。因此，将褪黑素包裹在生物相容性好、可生物降解且安全的纳米递送系统中，可以防止其在循环中降解；降低其毒性，延长半衰期，改善药代动力学特征，从而提高患者的依从性。因此，在多项研究中已使用纳米颗粒来递送褪黑素，本文旨在累积阐述这些研究结果。
