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从青少年到青年期心血管风险的转变——博加卢萨心脏研究:I. 生活方式改变的影响

Transitions of cardiovascular risk from adolescence to young adulthood--the Bogalusa Heart Study: I. Effects of alterations in lifestyle.

作者信息

Croft J B, Foster T A, Parker F C, Cresanta J L, Hunter S M, Webber L S, Srinivasan S R, Berenson G S

出版信息

J Chronic Dis. 1986;39(2):81-90. doi: 10.1016/0021-9681(86)90064-0.

Abstract

Adolescence and young adulthood represents a transition period for biologic and lifestyle characteristics. In a preliminary investigation of young adults (ages 18-20 years), the Bogalusa Heart Study documented patterns of alcohol, tobacco, and oral contraceptive use, as well as changes in education, occupational, marital and parenting status. Such behaviors accelerate the cardiovascular disease process and may differentially influence risk factor patterns of race and sex groups. Adverse levels of systolic blood pressure and alpha-lipoprotein cholesterol were more frequent in married vs single men; elevated triglyceride levels were more frequent in married vs single whites. However adverse levels of beta- and alpha-lipoprotein cholesterol were more frequent in nonparents than in parents. Cigarette smoking and oral contraceptive use were independently related to elevated beta-lipoprotein cholesterol and decreased alpha-lipoprotein cholesterol levels of young white women. Alcohol consumption was highest among white males, with 32% reporting daily consumption of the equivalent of two or more beers or one mixed drink. Alcohol consumption was negatively correlated with blood pressure in white males and positively correlated with alpha-lipoprotein cholesterol in black males. Since such lifestyle factors are related to physiologic risk factors that result in heart disease and adult cardiovascular morbidity and mortality in the older ages, early targeting during adolescence and young adulthood is important.

摘要

青少年和青年时期是生物和生活方式特征的过渡阶段。在一项针对年轻人(18至20岁)的初步调查中,博加卢萨心脏研究记录了酒精、烟草和口服避孕药的使用模式,以及教育、职业、婚姻和育儿状况的变化。这些行为会加速心血管疾病进程,可能对不同种族和性别人群的危险因素模式产生不同影响。已婚男性与单身男性相比,收缩压和α脂蛋白胆固醇的不良水平更为常见;已婚白人比单身白人甘油三酯水平升高更为常见。然而,非父母人群中β脂蛋白和α脂蛋白胆固醇的不良水平比父母人群更为常见。吸烟和使用口服避孕药与年轻白人女性β脂蛋白胆固醇升高和α脂蛋白胆固醇水平降低独立相关。白人男性的酒精消费量最高,32%的人报告每天饮用相当于两瓶或更多啤酒或一杯混合饮料的量。白人男性的酒精消费与血压呈负相关,黑人男性的酒精消费与α脂蛋白胆固醇呈正相关。由于这些生活方式因素与导致老年人心脏病以及成人心血管疾病发病率和死亡率的生理危险因素相关,因此在青少年和青年时期尽早进行干预很重要。

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