Yang Yanan, Han Xiao, Jiang Can, Chen Yu, Tang Xuli, Li Guoqiang
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China; College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, People's Republic of China.
Bioorg Chem. 2024 Dec;153:107897. doi: 10.1016/j.bioorg.2024.107897. Epub 2024 Oct 18.
Penisimplinoid A (1), the first andrastin-type meroterpenoid with an unprecedented 6/6/3/6/5/5 polycyclic systems, together with ten highly oxygenated andrastin-type meroterpenoids (2-11) and one known analogue (12), were co-isolated from the marine-derived fungus Penicillium simplicissimum. Their absolute configurations were determined by single-crystal X-ray diffraction analysis (Cu Kα), DP4+ probability analyses, and ECD quantum chemistry calculations. Biological evaluation revealed that 7 and 12 showed anti-inflammatory activities in the zebrafish assay, 6 exhibited cytotoxic activity against NCI-H446 tumor cells with an IC value of 6.49 μM, 7 and 11 exhibited significant promoting angio-genesis activities.
阴茎类倍半萜A（1）是首个具有前所未有的6/6/3/6/5/5多环体系的雄甾烷型半萜，与十种高度氧化的雄甾烷型半萜（2 - 11）及一种已知类似物（12）一起，从海洋来源的简单青霉中共同分离得到。它们的绝对构型通过单晶X射线衍射分析（Cu Kα）、DP4 +概率分析和ECD量子化学计算确定。生物学评价表明，7和12在斑马鱼实验中显示出抗炎活性，6对NCI - H446肿瘤细胞表现出细胞毒性活性，IC值为6.49 μM，7和11表现出显著的促血管生成活性。
