Song Linlin, Yang Caihong, Ji Guiyi, Hu Rong
Department of Gynecology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China; Reproductive Medicine Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China; Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Department of Gynecology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China; Reproductive Medicine Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.
J Reprod Immunol. 2024 Dec;166:104384. doi: 10.1016/j.jri.2024.104384. Epub 2024 Oct 19.
Endometriosis is characterized as a macrophage-related ailment due to its strong link with immune dysfunction. Understanding the status of macrophage polarization in the context of endometriosis-related infertility is crucial for advancing diagnostic and therapeutic strategies. Our comprehensive review delves into the foundational understanding of macrophages and their profound influence on both endometriosis and infertility. Additionally, we illuminate the complex role of macrophages in infertility and endometriosis specifically. Finally, we focused on four critical dimensions: follicular fluid, the intraperitoneal environment, endometrial receptivity, and strategies for managing endometriosis. It is clear that throughout the progression of endometriosis, the diverse polarization states of macrophages play a pivotal role in the internal reproductive environment of infertile individuals grappling with this condition. Modulating macrophage polarization in the reproductive environment of endometriosis patients could address infertility challenges more effectively, offering a promising pathway for treating infertility associated with endometriosis.
子宫内膜异位症因其与免疫功能障碍的紧密联系而被视为一种与巨噬细胞相关的疾病。了解子宫内膜异位症相关不孕症背景下巨噬细胞极化的状态对于推进诊断和治疗策略至关重要。我们的全面综述深入探讨了对巨噬细胞的基本认识及其对子宫内膜异位症和不孕症的深远影响。此外，我们还特别阐明了巨噬细胞在不孕症和子宫内膜异位症中的复杂作用。最后，我们聚焦于四个关键方面：卵泡液、腹腔内环境、子宫内膜容受性以及子宫内膜异位症的管理策略。显然，在子宫内膜异位症的整个发展过程中，巨噬细胞的不同极化状态在患有这种疾病的不孕个体的内部生殖环境中起着关键作用。调节子宫内膜异位症患者生殖环境中的巨噬细胞极化可以更有效地应对不孕挑战，为治疗与子宫内膜异位症相关的不孕症提供了一条有前景的途径。
