Xu Xize, Morton Mitchell P, Denagamage Sachira, Hudson Nyomi V, Nandy Anirvan S, Jadi Monika P
Department of Neuroscience, Yale University, New Haven, CT 06510, USA; Department of Psychiatry, Yale University, New Haven, CT 06510, USA; Kavli Institute for Neuroscience, Yale University, New Haven, CT 06510, USA.
Department of Neuroscience, Yale University, New Haven, CT 06510, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA.
Neuron. 2024 Dec 18;112(24):4081-4095.e5. doi: 10.1016/j.neuron.2024.09.021. Epub 2024 Oct 22.
Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet, how the spatial organization of objects influences this activity remains poorly understood. We investigate how inter-laminar information flow within the primary visual cortex (V1) is affected by visual stimuli in isolation or with flankers at spatial configurations that are known to cause non-uniform degradation of perception. By employing dimensionality reduction approaches to simultaneous, layer-specific population recordings, we establish that information propagation between cortical layers occurs along a structurally stable communication subspace. The spatial configuration of contextual stimuli differentially modulates inter-laminar communication efficacy, the balance of feedforward and effective feedback signaling, and contextual signaling in the superficial layers. Remarkably, these modulations mirror the spatially non-uniform aspects of perceptual degradation. Our results suggest a model of retinotopically non-uniform cortical connectivity in the output layers of V1 that influences information flow in the sensory hierarchy.
我们的视觉体验是感觉层级中神经元集群协同活动的结果。然而，物体的空间组织如何影响这种活动仍知之甚少。我们研究了初级视觉皮层（V1）内的层间信息流是如何受到孤立视觉刺激或在已知会导致感知不均匀退化的空间配置下带有侧翼刺激的影响。通过采用降维方法对同时进行的、特定层的群体记录进行分析，我们确定皮层层间的信息传播沿着一个结构稳定的通信子空间发生。上下文刺激的空间配置差异性地调节层间通信效率、前馈和有效反馈信号的平衡以及表层中的上下文信号。值得注意的是，这些调节反映了感知退化在空间上的非均匀方面。我们的结果提出了一个V1输出层中视网膜拓扑非均匀皮层连接的模型，该模型影响感觉层级中的信息流。
