Industrial Systems Biology Lab, Department of Bioinformatics, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620024, Tamil Nadu, India.
Industrial Systems Biology Lab, Department of Bioinformatics, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620024, Tamil Nadu, India.
Fish Shellfish Immunol. 2024 Nov;154:109978. doi: 10.1016/j.fsi.2024.109978. Epub 2024 Oct 21.
Fish diseases significantly challenge global aquaculture, causing substantial financial losses and impacting sustainability, trade, and socioeconomic conditions. Understanding microbial pathogenesis and virulence at the molecular level is crucial for disease prevention in commercial fish. This review provides genomic insights into fish pathogenic bacteria from a systems biology perspective, aiming to promote sustainable aquaculture. It covers the genomic characteristics of various fish pathogens and their industry impact. The review also explores the systems biology of zebrafish, fish bacterial pathogens, and probiotic bacteria, offering insights into fish production, potential vaccines, and therapeutic drugs. Genome-scale metabolic models aid in studying pathogenic bacteria, contributing to disease management and antimicrobial development. Researchers have also investigated probiotic strains to improve aquaculture health. Additionally, the review highlights bioinformatics resources for fish and fish pathogens, which are essential for researchers. Systems biology approaches enhance understanding of bacterial fish pathogens by revealing virulence factors and host interactions. Despite challenges from the adaptability and pathogenicity of bacterial infections, sustainable alternatives are necessary to meet seafood demand. This review underscores the potential of systems biology in understanding fish pathogen biology, improving production, and promoting sustainable aquaculture.
鱼类疾病对全球水产养殖业构成重大挑战，导致重大经济损失，并影响可持续性、贸易和社会经济状况。在分子水平上了解微生物发病机制和毒力对于商业鱼类的疾病预防至关重要。本综述从系统生物学的角度对鱼类病原菌的基因组进行了深入探讨，旨在促进可持续水产养殖。它涵盖了各种鱼类病原体的基因组特征及其对工业的影响。本综述还探讨了斑马鱼、鱼类病原菌和益生菌的系统生物学，为鱼类生产、潜在疫苗和治疗药物提供了新的见解。基因组规模的代谢模型有助于研究病原菌，有助于疾病管理和抗菌药物的开发。研究人员还研究了益生菌菌株，以改善水产养殖的健康状况。此外，本综述还强调了鱼类和鱼类病原体的生物信息学资源，这些资源对研究人员至关重要。系统生物学方法通过揭示毒力因子和宿主相互作用，增强了对鱼类病原菌的理解。尽管面临细菌感染的适应性和致病性的挑战，但为了满足海鲜需求，必须采用可持续的替代方案。本综述强调了系统生物学在理解鱼类病原体生物学、提高生产效率和促进可持续水产养殖方面的潜力。
