Albarella Deborah, Dall'Ara Paola, Rossi Luciana, Turin Lauretta
Department of Veterinary Medicine and Animal Sciences-DIVAS, Università degli Studi di Milano, 26900 Lodi, Italy.
Microorganisms. 2025 Apr 6;13(4):831. doi: 10.3390/microorganisms13040831.
Bacteriophages, or phages, which are viruses with specifically restricted tropism for bacteria, have regained interest in the last few decades as alternative therapeutic agents against antibiotic-resistant pathogenic bacteria in animals and humans worldwide. In this context, bacteriophage therapy has been developed to treat bacterial infections of cultured fish, shellfish, and crustaceans. Nowadays, aquaculture is the only feasible solution to meet the continuously growing global demand for high-quality seafood. As such, it is crucial to focus on controlling the spread of pathogenic bacteria, as they have a significant economic impact on aquaculture systems. Overall, the documented research supports the application of bacteriophage therapy in aquaculture, but also underlies the need for additional studies, as it is still mostly in the scientific stage. This review aims to highlight and critically examine recent advancements in the application of bacteriophages to treat the most common bacterial infectious diseases in both freshwater and saltwater aquaculture species, providing topical perspectives and innovative advances.
噬菌体，即对细菌具有特定受限嗜性的病毒，在过去几十年中重新引起了人们的关注，成为全球范围内对抗动物和人类中耐抗生素病原菌的替代治疗剂。在此背景下，噬菌体疗法已被开发用于治疗养殖鱼类、贝类和甲壳类动物的细菌感染。如今，水产养殖是满足全球对优质海鲜不断增长需求的唯一可行解决方案。因此，关注控制病原菌的传播至关重要，因为它们对水产养殖系统有重大经济影响。总体而言，已记录的研究支持噬菌体疗法在水产养殖中的应用，但也表明仍需要更多研究，因为它大多仍处于科学阶段。本综述旨在突出并批判性地审视噬菌体在治疗淡水和咸水养殖物种中最常见细菌传染病应用方面的最新进展，提供 topical 观点和创新进展。 （注：“topical”此处保留英文未翻译，可能是特定专业术语或有误，原文如此）
