Moorthy Dharsini Narayana, Dhinasekaran Durgalakshmi, Rebecca P N Blessy, Rajendran Ajay Rakkesh
Department of Medical Physics, Anna University, Chennai, Tamil Nadu, India.
Functional Nano-Materials (FuN) Laboratory, Department of Physics and Nanotechnology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
J Biophotonics. 2024 Dec;17(12):e202400243. doi: 10.1002/jbio.202400243. Epub 2024 Oct 23.
Optical biosensors are emerging as a promising technique for the sensitive and accurate detection of cancer biomarkers, enabling significant advancements in the field of early diagnosis. This study elaborates on the latest developments in optical biosensors designed for detecting cancer biomarkers, highlighting their vital significance in early cancer diagnosis. When combined with targeted nanoparticles, the bio-fluids can help in the molecular stage diagnosis of cancer. This enhances the discrimination of disease from the normal subjects drastically. The optical sensor methods that are involved in the disease diagnosis and imaging of cancer taken for the present review are surface plasmon resonance, localized surface plasmon resonance, fluorescence resonance energy transfer, surface-enhanced Raman spectroscopy and colorimetric sensing. The article meticulously describes the specific biomarkers and analytes that optical biosensors target. Beyond elucidating the underlying principles and applications, this article furnishes an overview of recent breakthroughs and emerging trends in the field. This encompasses the evolution of innovative nanomaterials and nanostructures designed to augment sensitivity and the incorporation of microfluidics for facilitating point-of-care testing, thereby charting a course towards prospective advancements.
光学生物传感器正成为一种用于灵敏、准确检测癌症生物标志物的有前途的技术，推动早期诊断领域取得重大进展。本研究阐述了用于检测癌症生物标志物的光学生物传感器的最新进展，强调了它们在早期癌症诊断中的重要意义。当与靶向纳米颗粒结合时，生物流体有助于癌症的分子阶段诊断。这极大地增强了疾病与正常受试者之间的区分度。本综述中涉及癌症疾病诊断和成像的光传感器方法有表面等离子体共振、局域表面等离子体共振、荧光共振能量转移、表面增强拉曼光谱和比色传感。文章详细描述了光学生物传感器所针对的特定生物标志物和分析物。除了阐明基本原理和应用外，本文还概述了该领域的最新突破和新兴趋势。这包括旨在提高灵敏度的创新纳米材料和纳米结构的发展，以及为促进即时检测而引入的微流体技术，从而为未来的进展指明方向。
