Japanese Red Cross Society Himeji Hospital, 1-12-1 Shimoteno, Himeji, Hyogo, Japan.
Sci Rep. 2024 Oct 23;14(1):25110. doi: 10.1038/s41598-024-72048-0.
We investigated the effect of retinal traction caused by epiretinal membranes (ERMs) on aniseikonia and retinal microstructures in 81 unilateral ERMs. Retinal traction was quantified by measuring the maximum depth of the retinal fold (MDRF) using en face optical coherence tomography (OCT) images. Measurements included the mean inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), central retinal thickness (CRT), and interocular ratios of the foveal avascular zone (FAZ) area (FAZ ratio). Significant correlations were found between the preoperative MDRF and preoperative aniseikonia (P < 0.001), INL thickness (P < 0.001), CRT (P < 0.001), and FAZ ratio (P = 0.003). Preoperative aniseikonia was significantly correlated with preoperative INL and OPL-ONL thicknesses (P < 0.001 and P = 0.020, respectively) and CRT (P = 0.003). Multiple regression analysis revealed that preoperative aniseikonia was significantly associated with preoperative MDRF, INL, and OPL-ONL thicknesses (P = 0.029, 0.006, and 0.006, respectively). Twenty-nine eyes underwent membrane peeling, resolving all retinal folds 6 months postoperatively. A significant correlation was observed between preoperative MDRF and postoperative aniseikonia (P = 0.011). Our findings suggest that retinal traction by ERM is significantly associated with aniseikonia both pre- and postoperatively, alongside other OCT parameters.
我们研究了 81 例单侧视网膜前膜（ERM）引起的视网膜牵引对不等像和视网膜微观结构的影响。使用共焦光学相干断层扫描（OCT）图像测量视网膜折叠的最大深度（MDRF）来量化视网膜牵引。测量包括平均内核层（INL）、外丛状层（OPL）、外核层（ONL）、中心视网膜厚度（CRT）和黄斑中心无血管区（FAZ）面积的眼间比值（FAZ 比）。我们发现术前 MDRF 与术前不等像（P < 0.001）、INL 厚度（P < 0.001）、CRT（P < 0.001）和 FAZ 比（P = 0.003）呈显著相关。术前不等像与术前 INL 和 OPL-ONL 厚度（P < 0.001 和 P = 0.020）和 CRT（P = 0.003）显著相关。多元回归分析显示，术前不等像与术前 MDRF、INL 和 OPL-ONL 厚度显著相关（P = 0.029、0.006 和 0.006）。29 只眼行膜剥除术，术后 6 个月所有视网膜折叠均消失。我们发现术前 MDRF 与术后不等像之间存在显著相关性（P = 0.011）。我们的研究结果表明，ERM 引起的视网膜牵引与术前和术后的不等像均显著相关，同时与其他 OCT 参数相关。
