Department of Biochemistry, Imo State University Owerri, Owerri, Imo State, Nigeria.
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.
BMC Complement Med Ther. 2024 Oct 23;24(1):374. doi: 10.1186/s12906-024-04681-1.
Tetrapleura tetraptera, a widely used medicinal plant in West Africa, has been traditionally employed for various ailments. Despite its folkloric significance, scientific validation of its safety and potential neuroactive properties remains limited.
This study aimed to investigate the acute and subchronic toxicity of Tetrapleura tetraptera hot water extract (HWETTF) in rats and to elucidate its phytochemical composition.
Acute oral toxicity was assessed in mice using the OECD guideline 423, while a 14-day repeat-dose toxicity study was conducted in rats. The phytochemical analysis included HPLC, FT-IR, and GC-MS.
HWETTF exhibited no significant toxicity in acute or subchronic studies, even at high doses. Phytochemical analysis revealed a diverse array of compounds, including those with potential GABAergic and CNS depressant activities.
Tetrapleura tetraptera demonstrated a favourable safety profile in rodents and possesses a rich phytochemical composition. Further research is warranted to explore its potential neuroactive properties and develop therapeutic applications.
在西非，四棱豆是一种被广泛应用于医学的植物，传统上被用于治疗各种疾病。尽管具有民间传说意义，但对其安全性和潜在神经活性特性的科学验证仍然有限。
本研究旨在评估四棱豆热水提取物（HWETTF）在大鼠中的急性和亚慢性毒性，并阐明其植物化学成分。
采用 OECD 指南 423 对小鼠进行急性口服毒性评估，对大鼠进行为期 14 天的重复剂量毒性研究。植物化学成分分析包括 HPLC、FT-IR 和 GC-MS。
HWETTF 在急性或亚慢性研究中均未表现出显著毒性，即使在高剂量下也是如此。植物化学成分分析显示了多种化合物，包括具有潜在 GABA 能和中枢神经系统抑制活性的化合物。
四棱豆在啮齿动物中表现出良好的安全性，且具有丰富的植物化学成分。需要进一步研究以探索其潜在的神经活性特性并开发治疗应用。
