Wu Meina, Xue Pei, Yan Jinzhu, Benedict Christian
Department of Neurology and Sleep Medical Center, Fujian Provincial Governmental Hospital, Fuzhou, China.
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
J Sleep Res. 2025 Jun;34(3):e14385. doi: 10.1111/jsr.14385. Epub 2024 Oct 23.
Obstructive sleep apnea frequently coexists with epilepsy, potentially influencing its pathophysiology. However, the effect of obstructive sleep apnea severity on interictal epileptiform discharges is not well understood. To explore this, we studied 108 Asian patients with epilepsy who underwent single-night polysomnography. We utilized generalized linear models, adjusting for age, sex, epilepsy type (focal versus generalized), antiepileptic medication use and disease duration, to analyse the relationship between obstructive sleep apnea severity, as measured by the apnea-hypopnea index, and interictal epileptiform discharge frequency during non-rapid eye movement and rapid eye movement sleep. Our analysis revealed that severe obstructive sleep apnea (apnea-hypopnea index ≥ 30) was associated with a higher frequency of interictal epileptiform discharges during non-rapid eye movement sleep (p = 0.04), but no such association was observed during rapid eye movement sleep. Additionally, the frequency of interictal epileptiform discharges in non-rapid eye movement sleep was positively correlated with the wake time between sleep onset and offset (p = 0.03). Further studies are warranted to validate our findings across diverse ethnicities, and over multiple nights of sleep and interictal epileptiform discharge recordings.
阻塞性睡眠呼吸暂停常与癫痫共存，可能影响其病理生理过程。然而，阻塞性睡眠呼吸暂停严重程度对发作间期癫痫样放电的影响尚不清楚。为了探究这一问题，我们研究了108例接受单夜多导睡眠监测的亚洲癫痫患者。我们使用广义线性模型，对年龄、性别、癫痫类型（局灶性与全身性）、抗癫痫药物使用情况和病程进行校正，以分析通过呼吸暂停低通气指数测量的阻塞性睡眠呼吸暂停严重程度与非快速眼动睡眠和快速眼动睡眠期间发作间期癫痫样放电频率之间的关系。我们的分析显示，重度阻塞性睡眠呼吸暂停（呼吸暂停低通气指数≥30）与非快速眼动睡眠期间发作间期癫痫样放电频率较高相关（p = 0.04），但在快速眼动睡眠期间未观察到这种关联。此外，非快速眼动睡眠期间发作间期癫痫样放电频率与入睡至醒来的清醒时间呈正相关（p = 0.03）。有必要进行进一步研究，以在不同种族、多个睡眠夜晚和发作间期癫痫样放电记录中验证我们的发现。
