Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Department of Population Health Sciences Spencer Fox Eccles School of Medicine, University of Utah Intermountain Healthcare, University of Utah, Salt Lake City, Utah, USA.
Cancer Med. 2024 Oct;13(20):e70260. doi: 10.1002/cam4.70260.
Approximately one-third of US adults have a tattoo, and the prevalence is increasing. Tattooing can result in long-term exposure to carcinogens and inflammatory and immune responses.
We examined tattooing and risk of hematologic cancers in a population-based case-control study with 820 cases diagnosed 2019-2021 and 8200 frequency-matched controls, ages 18-79 years. We calculated odds ratios (OR) and 95% confidence intervals (CI) using multivariable-adjusted logistic regression models.
The prevalence of tattooing was 22% among Hodgkin lymphoma (HL) cases, 11% among non-Hodgkin lymphoma (NHL) cases, 16% among myeloid neoplasm cases, and 15% among controls. Though there were no clear patterns of associations between ever receiving a tattoo and risk of HL, NHL, or myeloid neoplasms overall, in analyses restricted to ages 20-60 years, ever receiving a tattoo (OR 2.06 [95% CI 1.01, 4.20]) and receiving a tattoo 10+ years prior (OR 2.64 [95% CI 1.23, 5.68]) were associated with an aggregated group of rarer mature B-cell NHLs. We also observed elevated risks for a 10+ year latency for myelodysplastic syndromes and chronic myeloid leukemia (OR 1.48 [95% CI 0.40, 5.41], and OR 1.24 [95% CI 0.45, 3.43], respectively).
Though estimates were imprecise, we found some suggestive evidence that tattooing may be associated with an increased risk of certain hematologic cancer subtypes. With an estimated 46% prevalence of tattooing in US individuals ages 30-49, additional studies are needed to understand the degree to which these exposures may be associated with hematologic cancer risk.
大约三分之一的美国成年人有纹身，而且这一比例还在增加。纹身可能会导致长期接触致癌物质以及炎症和免疫反应。
我们在一项基于人群的病例对照研究中，对 2019 年至 2021 年期间诊断出的 820 例病例和 8200 例年龄在 18 至 79 岁之间的频率匹配对照者进行了调查，以研究纹身与血液系统癌症的关系。我们使用多变量调整的逻辑回归模型计算了比值比（OR）和 95%置信区间（CI）。
霍奇金淋巴瘤（HL）病例中纹身的比例为 22%，非霍奇金淋巴瘤（NHL）病例中为 11%，髓系肿瘤病例中为 16%，对照组中为 15%。虽然在总体上，HL、NHL 或髓系肿瘤患者中，是否曾接受过纹身与风险之间没有明显的关联模式，但在对年龄在 20 至 60 岁之间的人群进行分析时，曾接受过纹身（OR 2.06 [95% CI 1.01，4.20]）和纹身 10 年以上（OR 2.64 [95% CI 1.23，5.68]）与更罕见的成熟 B 细胞 NHL 亚群有关。我们还观察到，潜伏期在 10 年以上的骨髓增生异常综合征和慢性髓系白血病的风险升高（OR 1.48 [95% CI 0.40，5.41]，和 OR 1.24 [95% CI 0.45，3.43]）。
尽管估计值不够精确，但我们发现了一些提示性证据，表明纹身可能与某些血液系统癌症亚型的风险增加有关。在美国 30 至 49 岁的人群中，纹身的估计患病率为 46%，因此需要开展更多的研究来了解这些暴露与血液系统癌症风险的关联程度。
