Luo Tingting, Che Qingya, Guo Ziyi, Song Tingxia, Zhao Juanjuan, Xu Delin
Department of Medical Instrumental Analysis, Zunyi Medical University, Zunyi, China.
Department of Cell Biology, Zunyi Medical University, Zunyi, China.
Front Pharmacol. 2024 Oct 9;15:1442854. doi: 10.3389/fphar.2024.1442854. eCollection 2024.
The gut microbiota offers numerous benefits to the human body, including the promotion of nutrient absorption, participation in metabolic processes, and enhancement of immune function. Recent studies have introduced the concept of the gut-organ axis, which encompasses interactions such as the gut-brain axis, gut-liver axis, and gut-lung axis. This concept underscores the complex interplay between gut microbiota and various organs and tissues, including the brain, heart, lungs, liver, kidneys, muscles, and bones. Growing evidence indicates that gut microbiota can influence the onset and progression of multi-organ system diseases through their effects on the gut-organ axis. Traditional Chinese medicine has demonstrated significant efficacy in regulating the gastrointestinal system, leveraging its unique advantages. Considerable advancements have been made in understanding the role of gut microbiota and the gut-organ axis within the mechanisms of action of traditional Chinese medicine. This review aims to elucidate the roles of gut microbiota and the gut-organ axis in human health, explore the potential connections between traditional Chinese medicine and gut microbiota, and examine the therapeutic effects of traditional Chinese medicine on the microbiota-gut-organ axis. Furthermore, the review addresses the limitations and challenges present in current research while proposing potential directions for future investigations in this area.
肠道微生物群对人体有诸多益处，包括促进营养吸收、参与代谢过程以及增强免疫功能。最近的研究引入了肠-器官轴的概念，其中包括肠-脑轴、肠-肝轴和肠-肺轴等相互作用。这一概念强调了肠道微生物群与包括大脑、心脏、肺、肝脏、肾脏、肌肉和骨骼在内的各种器官和组织之间的复杂相互作用。越来越多的证据表明，肠道微生物群可通过其对肠-器官轴的影响来影响多器官系统疾病的发生和发展。传统中医在调节胃肠系统方面已显示出显著疗效，发挥了其独特优势。在理解肠道微生物群和肠-器官轴在传统中医作用机制中的作用方面已取得了相当大的进展。本综述旨在阐明肠道微生物群和肠-器官轴在人类健康中的作用，探索传统中医与肠道微生物群之间的潜在联系，并研究传统中医对微生物群-肠-器官轴的治疗效果。此外，本综述还讨论了当前研究中存在的局限性和挑战，同时提出了该领域未来研究的潜在方向。
