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效应记忆CD4 T细胞在介导肠道微生物群属对阿尔茨海默病影响中的作用：一项孟德尔随机化研究

The involvement of effector memory CD4 T cells in mediating the impact of genus gut microbiota on Alzheimer's disease: a Mendelian randomization study.

作者信息

Zhang Huachang, Wang Yudong, Zhao Hui, Wang Wei, Han Fabin

机构信息

The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng, Shandong, China.

Department of Nursing, Liaocheng People's Hospital, Liaocheng, Shandong, China.

出版信息

Front Aging Neurosci. 2024 Aug 7;16:1423707. doi: 10.3389/fnagi.2024.1423707. eCollection 2024.

DOI:10.3389/fnagi.2024.1423707
PMID:39170894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11335717/
Abstract

OBJECTIVE

This study aimed to investigate the causal relationship between gut microbiota characteristics (207 taxa and 205 pathways) and Alzheimer's disease and determine and quantify the role of immune cells as potential mediators.

METHODS

Gut microbiota characteristics (207 taxa and 205 pathways) were obtained from the NHGRI-EBI GWAS Catalog project, while Alzheimer's disease data and 731 immune cell characteristics were obtained from the IEU Open GWAS project. Two-sample Mendelian randomization (MR) was conducted to determine whether gut microbiota characteristics (207 taxa and 205 pathways) were causally related to Alzheimer's disease. Furthermore, two-step MR was employed to quantify the proportion of the effect of immune cell characteristics mediated by gut microbiota characteristics (207 taxa and 205 pathways) on Alzheimer's disease.

RESULTS

A total of 17 immune cell characteristics were identified as potential mediators for 13 gut microbiota influencing Alzheimer's disease, with Effector Memory CD4+ T-cell Absolute Count accounted for 8.99% of the causal relationship between genus and Alzheimer's disease.

CONCLUSION

In summary, our research confirms a causal relationship between gut microbiota and Alzheimer's disease, with immune cells contributing to a significant portion of the effect. However, the full mediators of gut microbiota's impact on Alzheimer's disease remain unclear. Further investigation is warranted to explore additional potential risk factors acting as mediators.

摘要

目的

本研究旨在探讨肠道微生物群特征（207个分类群和205条通路）与阿尔茨海默病之间的因果关系，并确定和量化免疫细胞作为潜在介导者的作用。

方法

肠道微生物群特征（207个分类群和205条通路）来自NHGRI-EBI全基因组关联研究目录项目，而阿尔茨海默病数据和731个免疫细胞特征来自IEU开放全基因组关联研究项目。采用两样本孟德尔随机化（MR）方法来确定肠道微生物群特征（207个分类群和205条通路）是否与阿尔茨海默病存在因果关系。此外，采用两步MR方法来量化肠道微生物群特征（207个分类群和205条通路）介导的免疫细胞特征对阿尔茨海默病影响的比例。

结果

共确定了17个免疫细胞特征作为13种影响阿尔茨海默病的肠道微生物群的潜在介导者，其中效应记忆CD4 + T细胞绝对计数在属与阿尔茨海默病之间的因果关系中占8.99%。

结论

总之，我们的研究证实了肠道微生物群与阿尔茨海默病之间的因果关系，免疫细胞在很大一部分影响中起作用。然而，肠道微生物群对阿尔茨海默病影响的完整介导者仍不清楚。有必要进一步研究以探索作为介导者的其他潜在危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/bb7520b3ba92/fnagi-16-1423707-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/3ce7757007a9/fnagi-16-1423707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/cc5e1a020f2d/fnagi-16-1423707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/f4e5820c4018/fnagi-16-1423707-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/5724a7afdd8b/fnagi-16-1423707-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/b4905214076a/fnagi-16-1423707-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/bb7520b3ba92/fnagi-16-1423707-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/3ce7757007a9/fnagi-16-1423707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/cc5e1a020f2d/fnagi-16-1423707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/f4e5820c4018/fnagi-16-1423707-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/5724a7afdd8b/fnagi-16-1423707-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/b4905214076a/fnagi-16-1423707-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613d/11335717/bb7520b3ba92/fnagi-16-1423707-g006.jpg

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