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Interferon Interrupted: Are P2Y Antagonists the Next Step to Target Platelets in Autoimmunity?

作者信息

Roweth Harvey G

机构信息

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; and the Harvard Medical School, Boston, Massachusetts, USA.

出版信息

JACC Basic Transl Sci. 2024 Sep 23;9(9):1141-1143. doi: 10.1016/j.jacbts.2024.06.011. eCollection 2024 Sep.

DOI:10.1016/j.jacbts.2024.06.011
PMID:39444935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11494389/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/11494389/2c909d6e01c9/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/11494389/2c909d6e01c9/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98f4/11494389/2c909d6e01c9/ga1.jpg

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本文引用的文献

1
Alterations in the megakaryocyte transcriptome impacts platelet function in sepsis and COVID-19 infection.巨核细胞转录组的改变影响脓毒症和 COVID-19 感染中的血小板功能。
Thromb Res. 2023 Nov;231:247-254. doi: 10.1016/j.thromres.2023.05.015. Epub 2023 May 19.
2
CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.经 CRISPR 编辑的巨核细胞用于快速筛选血小板基因功能。
Blood Adv. 2021 May 11;5(9):2362-2374. doi: 10.1182/bloodadvances.2020004112.
3
The impact of clopidogrel on plasma-soluble CD40 ligand levels in systemic lupus erythematosus patients: the CLOPUS phase I/II pilot study.
氯吡格雷对系统性红斑狼疮患者血浆可溶性CD40配体水平的影响：CLOPUS I/II期初步研究
Joint Bone Spine. 2021 Mar;88(2):105097. doi: 10.1016/j.jbspin.2020.105097. Epub 2020 Nov 2.
4
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.S6K1 和 mTOR 调节 Rac1 驱动的血小板活化和聚集。
Blood. 2011 Sep 15;118(11):3129-36. doi: 10.1182/blood-2011-02-331579. Epub 2011 Jul 14.
5
Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus.血小板 CD154 增强系统性红斑狼疮中浆细胞样树突状细胞分泌干扰素-α。
Sci Transl Med. 2010 Sep 1;2(47):47ra63. doi: 10.1126/scitranslmed.3001001.
6
Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease.系统性红斑狼疮患者的血小板转录谱和蛋白表达：I 型干扰素系统的上调与血管疾病强烈相关。
Blood. 2010 Sep 16;116(11):1951-7. doi: 10.1182/blood-2010-03-274605. Epub 2010 Jun 10.
7
Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.雷帕霉素哺乳动物靶点（mTOR）调节巨核细胞祖细胞的增殖以及巨核细胞分化的后期阶段。
Blood. 2006 Mar 15;107(6):2303-10. doi: 10.1182/blood-2005-07-3005. Epub 2005 Nov 10.
8
Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus.系统性红斑狼疮患者血小板ADP受体P2Y(12)和簇集素的转录下调
J Thromb Haemost. 2004 Aug;2(8):1436-42. doi: 10.1111/j.1538-7836.2004.00854.x.