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一种由卡贝尔种子提取物组成的饲料添加剂用于除鳍鱼外的所有动物物种的安全性和有效性(NOR-FEED SAS)。

Safety and efficacy of a feed additive consisting of a C.Abel seed extract for use in all animal species except fin fish (NOR-FEED SAS).

作者信息

Villa Roberto Edoardo, Azimonti Giovanna, Bonos Eleftherios, Christensen Henrik, Durjava Mojca, Dusemund Birgit, Gehring Ronette, Glandorf Boet, Kouba Maryline, López-Alonso Marta, Marcon Francesca, Nebbia Carlo, Pechová Alena, Prieto-Maradona Miguel, Röhe Ilen, Theodoridou Katerina, Bastos Maria de Lourdes, Brantom Paul, Chesson Andrew, Schlatter Josef, Westendorf Johannes, Galobart Jaume, Innocenti Matteo Lorenzo, Ortuño Jordi, Pizzo Fabiola, Radovnikovic Anita, Tarrés-Call Jordi, Vettori Maria Vittoria, Manini Paola

出版信息

EFSA J. 2024 Oct 23;22(10):e9022. doi: 10.2903/j.efsa.2024.9022. eCollection 2024 Oct.

Abstract

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a C.Abel seed extract (Cosap®) as technological feed additive for all animal species except fin fish. In the absence of adequate tolerance studies in the target species or toxicological studies with the additive under assessment, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the safety of extract for the target species. The use of the additive in animal nutrition is not expected to cause concern for consumer safety. The additive is considered as irritant to the eyes and mucous membranes. No conclusions can be reached on the potential of the additive to be irritant to the skin or to be a dermal sensitiser. The use of the additive under the proposed conditions of use is considered safe for the terrestrial compartment. However, no conclusion can be reached on the safety of the additive for the environment when used in feed of aquatic animals other than fin fish. The Panel concluded that the additive has the potential to be efficacious as an emulsifier when used according to proposed conditions of use.

摘要

应欧盟委员会的要求,欧洲食品安全局(EFSA)被要求就一种C.Abel种子提取物(Cosap®)作为除鳍鱼以外所有动物物种的技术饲料添加剂的安全性和有效性发表科学意见。由于缺乏在目标物种中进行的充分耐受性研究或对所评估添加剂的毒理学研究,EFSA动物饲料添加剂和产品或物质专家小组(FEEDAP)无法就该提取物对目标物种的安全性得出结论。预计在动物营养中使用该添加剂不会引起消费者安全问题。该添加剂被认为对眼睛和粘膜有刺激性。无法就该添加剂对皮肤的刺激性或皮肤致敏性得出结论。在拟议的使用条件下使用该添加剂被认为对陆生生物是安全的。然而,当用于鳍鱼以外的水生动物饲料时,无法就该添加剂对环境的安全性得出结论。专家小组得出结论,按照拟议的使用条件使用时,该添加剂有作为乳化剂发挥功效的潜力。

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Guidance on the assessment of the safety of feed additives for the users.饲料添加剂使用者安全评估指南。
EFSA J. 2023 Dec 6;21(12):e8469. doi: 10.2903/j.efsa.2023.8469. eCollection 2023 Dec.
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Genotoxicity assessment of chemical mixtures.化学混合物的遗传毒性评估。
EFSA J. 2018 Dec 18;17(1):e05519. doi: 10.2903/j.efsa.2019.5519. eCollection 2019 Jan.
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Guidance on the assessment of the efficacy of feed additives.饲料添加剂功效评估指南。
EFSA J. 2018 May 7;16(5):e05274. doi: 10.2903/j.efsa.2018.5274. eCollection 2018 May.
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Saponins from seeds of Genus Camellia: Phytochemistry and bioactivity.山茶属种子中的皂苷:植物化学与生物活性。
Phytochemistry. 2018 May;149:42-55. doi: 10.1016/j.phytochem.2018.02.002. Epub 2018 Feb 17.
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The influence of saponins on cell membrane cholesterol.皂甙对细胞膜胆固醇的影响。
Bioorg Med Chem. 2013 Nov 15;21(22):7118-24. doi: 10.1016/j.bmc.2013.09.008. Epub 2013 Sep 14.

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