Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Front Immunol. 2024 Oct 9;15:1447719. doi: 10.3389/fimmu.2024.1447719. eCollection 2024.
The cGAS-STING pathway has become a crucial role in the detection of cytosolic DNA and the initiation of immune responses. The cGAS-STING pathway not only mediates protective immune defense against various DNA-containing pathogens but also detects tumor-derived DNA to generate intrinsic anti-tumor immunity. However, abnormal activation of the cGAS-STING pathway by self-DNA can also lead to autoimmune diseases and inflammatory disorders. This article reviews the mechanisms and functions of the cGAS-STING pathway, as well as the latest research progress in female reproductive-related diseases. We focus on the regulatory mechanisms and roles of this pathway in common female reproductive disorders, discuss the clinical potential of the cGAS-STING pathway as biomarkers and therapeutic agents for female reproductive diseases, as well as the research controversies, technical issues, and biological knowledge gaps that need to be resolved. Furthermore, we provide new ideas for the treatment and prevention of these diseases.
cGAS-STING 通路在检测细胞溶质 DNA 和启动免疫反应方面发挥着关键作用。cGAS-STING 通路不仅介导针对各种含有 DNA 的病原体的保护性免疫防御，还能检测肿瘤源性 DNA 以产生内在抗肿瘤免疫。然而，自身 DNA 的异常激活也会导致自身免疫性疾病和炎症性疾病。本文综述了 cGAS-STING 通路的机制和功能，以及其在女性生殖相关疾病中的最新研究进展。我们重点讨论了该通路在常见女性生殖障碍中的调控机制和作用，探讨了 cGAS-STING 通路作为女性生殖疾病生物标志物和治疗剂的临床潜力，以及需要解决的研究争议、技术问题和生物学知识空白。此外，我们为这些疾病的治疗和预防提供了新的思路。
