Lee Sang Min, Hong Minha, Ryoo Jae-Hong
Department of Psychiatry, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Department of Psychiatry, Myongji Hospital, Hanyang University College of Medicine, Goyang, Republic of Korea.
Front Neurol. 2024 Oct 9;15:1448428. doi: 10.3389/fneur.2024.1448428. eCollection 2024.
Excessive abdominal adiposity represents a cardiovascular disease risk factor. Waist circumference (WC) reflects abdominal adiposity and is known as an easy-to-measure indicator of obesity. This study aimed to evaluate the relationship between WC level and the development of cerebral infarction in Koreans.
209,442 Koreans were included among the general population registered in the National Health Information Database. Depending on the degree of WC, the possibility of cerebral infarction was tracked for 4.37 person-years. Identification of patients with cerebral infarction was confirmed through the diagnostic code ICD I63 of inpatient or outpatient. Participants' data were analyzed by sex. The hazard ratios (HRs) and confidence interval (CI) for cerebral infarction were calculated using the Cox proportional hazards model.
Between 2009 and 2013, 2,403 cases (1.15%) of cerebral infarction occurred during the follow-up period of 915,223.6 person-years. The HRs (95% CI) for incident cerebral infarction in men was adjusted for multiple covariates, and comparison of WC levels second, third, and fourth quartile with the first quartile showed 1.10 (0.94-1.28), 1.11 (0.95-1.30), and 1.24 (1.07-1.45), respectively (P for trend 0.045). This association was not significant in women (P for trend 0.619). The severity of WC levels in men is significantly associated with the risk of developing cerebral infarction in Koreans. This finding indicates that other measurements for excessive adipose visceral tissue, except abdominal circumference, need to be taken into account to identify the risk of cerebral infarction in women.
腹部脂肪过多是心血管疾病的一个危险因素。腰围（WC）反映腹部脂肪堆积情况，是一种易于测量的肥胖指标。本研究旨在评估韩国人腰围水平与脑梗死发生之间的关系。
纳入韩国国家健康信息数据库登记的209442名普通人群。根据腰围程度，对脑梗死发生可能性进行了4.37人年的跟踪。通过住院或门诊的诊断编码ICD I63确诊脑梗死患者。按性别对参与者数据进行分析。使用Cox比例风险模型计算脑梗死的风险比（HRs）和置信区间（CI）。
在2009年至2013年期间，915223.6人年的随访期内发生了2403例（1.15%）脑梗死。对男性新发脑梗死的HRs（95%CI）进行多协变量调整后，将第二、第三和第四四分位数的腰围水平与第一四分位数进行比较，结果分别为1.10（0.94 - 1.28）、1.11（0.95 - 1.30）和1.24（1.07 - 1.45）（趋势P值为0.045）。女性中这种关联不显著（趋势P值为0.619）。韩国男性腰围水平的严重程度与脑梗死发生风险显著相关。这一发现表明，要确定女性脑梗死风险，除腹围外还需要考虑其他测量过多内脏脂肪组织的方法。
