Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Juarez City, Chihuahua, Mexico.
Research Division, Faculty of Medicine, Juarez University of the State of Durango, Durango City, Mexico.
Biomed Res Int. 2024 Oct 15;2024:5560866. doi: 10.1155/2024/5560866. eCollection 2024.
A biomarker is defined as a characteristic that is measured as an indicator of a normal biological or pathological process, a response to an exposure or intervention. Biomarkers with a diagnostic approach must identify not only the presence but also the absence of the disease with high precision, so having the biological source of the said marker is of vital importance to ensure precision and accuracy; the aim was to carry out a review of its diagnostic potential. The search strategy was carried out in three databases: PubMed, ScienceDirect, and Scopus. The keywords that were used were as follows: "gingival crevicular fluid", "Biomarker", and "Diagnosis", using the Boolean operator "AND". The filter was used at 10 years. Within the type of molecules most studied, the cytokine family was the most abundant with 25.42% of the studies, followed by metalloproteinases and proteins with 16.9% each one. Studies that included RNA-type genetic material were less frequently found. As has been demonstrated, the use of GCF as a source of biomolecules for diagnostic use has been increasing, both for oral diseases, which reflects the local conditions of the disease; it also has the ability to reflect the development of distant diseases; and this is because GCF is a blood ultrafiltrate.
生物标志物被定义为作为正常生物学或病理过程、对暴露或干预的反应的指标而测量的特征。具有诊断方法的生物标志物不仅必须高度精确地识别疾病的存在，而且还必须识别疾病的不存在，因此，具有所述标志物的生物来源对于确保精确性和准确性至关重要；目的是对其诊断潜力进行综述。搜索策略在三个数据库中进行：PubMed、ScienceDirect 和 Scopus。使用的关键词如下：“牙龈沟液”、“生物标志物”和“诊断”，使用布尔运算符“AND”。过滤器使用了 10 年。在研究最多的分子类型中，细胞因子家族最丰富，占 25.42%，其次是金属蛋白酶和蛋白质，各占 16.9%。较少发现包括 RNA 型遗传物质的研究。正如已经证明的那样，使用 GCF 作为生物标志物用于诊断的来源的使用越来越多，既用于口腔疾病，这反映了疾病的局部情况；它还有能力反映远处疾病的发展；这是因为 GCF 是血液超滤物。
