Guo Zhihui, Wu Shouling, Zheng Mengyi, Xia Pengfei, Li Qiuyun, He Qing, Song Zhenqiang
Tianjin Medical University, Tianjin, China.
Department of Cardiology, Kailuan General Hospital, Tangshan, China.
J Diabetes Investig. 2025 Jan;16(1):129-136. doi: 10.1111/jdi.14316. Epub 2024 Oct 24.
AIMS/INTRODUCTION: We investigated the association between impaired fasting glucose (IFG) and cardiometabolic multimorbidity (CMM) in the Chinese population.
We included 119,368 participants, free of diabetes mellitus and cardiovascular disease, who participated in the health examination (2006, 2008, 2010) of the Kailuan Study. According to World Health Organization diagnostic criteria, participants were divided into normal fasting blood glucose (FBG) (<6.1 mmol/L) and IFG (FBG 6.1-6.9 mmol/L) groups. CMM was defined as having two or more cardiometabolic diseases, including myocardial infarction, stroke and diabetes mellitus. We used Cox proportional hazards models to evaluate associations between IFG and CMM.
During a median follow-up period of 13.94 years, 2,432 CMM incident events occurred. After adjusting potential confounders, the hazard ratio (HR) and 95% confidence interval (CI) for CMM in the IFG group was 2.83 (95% CI 2.58-3.10) versus the normal FBG group. The HR of IFG for diabetes mellitus was 3.43 (95% CI 3.30-3.55), which was >1.25 (95% CI 1.13-1.37) for myocardial infarction, 1.16 (95% CI 1.07-1.25) for ischemic stroke and 1.06 (95% CI 0.88-1.27) for hemorrhagic stroke. Compared with normal FBG, HRs for risk of IFG for CMM were 2.73 (95% CI 2.48-3.02) in men and 3.86 (95% CI 2.92-5.09) in women.
IFG was a risk factor for CMM. The effect of IFG on diabetes mellitus was stronger than that on other cardiometabolic diseases. The effects of IFG for CMM differed by sex.
目的/引言：我们研究了中国人群中空腹血糖受损（IFG）与心脏代谢性多种疾病（CMM）之间的关联。
我们纳入了119368名无糖尿病和心血管疾病的参与者，他们参加了开滦研究的健康检查（2006年、2008年、2010年）。根据世界卫生组织诊断标准，参与者被分为空腹血糖正常（FBG）（<6.1 mmol/L）和IFG（FBG 6.1 - 6.9 mmol/L）组。CMM被定义为患有两种或更多种心脏代谢性疾病，包括心肌梗死、中风和糖尿病。我们使用Cox比例风险模型来评估IFG与CMM之间的关联。
在中位随访期13.94年期间，发生了2432例CMM事件。在调整潜在混杂因素后，IFG组CMM的风险比（HR）和95%置信区间（CI）为2.83（95% CI 2.58 - 3.10），而正常FBG组为对照。IFG患糖尿病的HR为3.43（95% CI 3.30 - 3.55），心肌梗死的HR>1.25（95% CI 1.13 - 1.37），缺血性中风的HR为1.16（95% CI 1.07 - 1.25），出血性中风的HR为1.06（95% CI 0.88 - 1.27）。与正常FBG相比，男性IFG患CMM风险的HR为2.73（95% CI 2.48 - 3.02），女性为3.86（95% CI 2.92 - 5.09）。
IFG是CMM的一个危险因素。IFG对糖尿病的影响强于对其他心脏代谢性疾病的影响。IFG对CMM的影响存在性别差异。
