Kouba Bruna R, Rodrigues Ana Lúcia S
Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.
Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.
Pharmacol Biochem Behav. 2024 Dec;245:173899. doi: 10.1016/j.pbb.2024.173899. Epub 2024 Oct 22.
The pathophysiology of a wide range of central nervous system (CNS) disorders, such as neurodegenerative and psychiatric diseases, has been associated with impairment of neurogenic and synaptogenic processes. Therefore, pharmacological and/or nutritional strategies based on the stimulation and/or restoration of these processes may have beneficial effects against diseases in which these processes are impaired. In this context, vitamin D has emerged as a promising neuroprotective compound. Due to its pleiotropic properties, it can interact with multiple molecular targets and thereby affect different cell types, including neurons and glial cells. This neurosteroid contributes to CNS homeostasis by non-genomic and genomic mechanisms through its interaction with vitamin D receptors (VDRs). Among several properties of this vitamin, its role in neuronal proliferation and differentiation as well as in synaptic plasticity has received attention. Considering this background, this narrative review aims to highlight the neuroplasticity-related mechanisms of vitamin D that may be associated with its neuroprotective effects.
多种中枢神经系统（CNS）疾病，如神经退行性疾病和精神疾病，其病理生理学与神经发生和突触形成过程的受损有关。因此，基于刺激和/或恢复这些过程的药理学和/或营养策略可能对这些过程受损的疾病具有有益作用。在这种背景下，维生素D已成为一种有前景的神经保护化合物。由于其多效性，它可以与多个分子靶点相互作用，从而影响不同的细胞类型，包括神经元和神经胶质细胞。这种神经甾体通过与维生素D受体（VDR）相互作用，通过非基因组和基因组机制促进中枢神经系统的稳态。在这种维生素的多种特性中，其在神经元增殖和分化以及突触可塑性中的作用受到了关注。考虑到这一背景，本叙述性综述旨在强调维生素D可能与其神经保护作用相关的神经可塑性相关机制。
