Research Institute for Marine Traditional Chinese Medicine, The SATCM's Key Unit of Discovering and Developing New Marine TCM Drugs, Key Laboratory of Marine Traditional Chinese Medicine in Shandong Universities, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Qingdao Academy of Chinese Medical Sciences Shandong University of Traditional Chinese Medicine, Qingdao Key Laboratory of Research in Marine Traditional Chinese Medicine, Qingdao Key Technology Innovation Center of Marine Traditional Chinese Medicine's Deep Development and Industrialization, Qingdao, 266114, China.
National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land, Dongying, 257345, China; Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, 266101, China.
J Ethnopharmacol. 2025 Jan 30;337(Pt 3):118967. doi: 10.1016/j.jep.2024.118967. Epub 2024 Oct 22.
Apocynum venetum L., commonly known as Luobuma, has been widely utilized in East Asia and Southeast Asia for its medicinal properties and health benefits. Its first documented mention is found in the classic Chinese text Divine Farmer's Materia Medica from the Eastern Han Dynasty, in which it is referred to as "Zeqi." In 1977, the leaves of A. venetum were officially included in the Chinese Pharmacopoeia. The 2020 edition of the Chinese Pharmacopoeia attributes various effects to A. venetum, including liver pacification, spirit tranquilization, heat clearance, and water disinhibition.
Despite the abundance of recent studies on A. venetum leaves, a comprehensive review of the literature that incorporates the latest research findings is lacking. The primary goal of this article is to provide researchers with a more comprehensive and detailed reference by conducting an in-depth analysis of the traditional medicinal uses, phytochemicals, and pharmacological mechanisms associated with A. venetum leaves.
This research project includes original articles published from 1957 to 2024 from various databases, including Web of Science, PubMed, and the China National Knowledge Infrastructure (CNKI). Furthermore, data from ancient Chinese herbal texts, doctoral dissertations, and master's theses were examined, encompassing a total of 89 records.
A. venetum, which is widely utilized in traditional ethnic medicine, possesses a diverse botanical chemical composition with 371 chemical constituents, including flavonoids, terpenoids, steroids, phenylpropanoids, organic acids, polysaccharides, and volatile oils. Although the water-soluble components of A. venetum remain incompletely understood, empirical evidence and scholarly literature have demonstrated the beneficial pharmacological effects of its extracts and chemical constituents, particularly the flavonoids, which offer various effects, including cardiovascular protection, anticancer properties, antioxidant activity, and anti-inflammatory effects.
This review presents a comprehensive review of the traditional and contemporary medicinal applications of A. venetum. These findings indicate that A. venetum is effective in treating hypertension and also shows promise in addressing hyperlipidemia, atherosclerosis, and myocardial damage. This discovery may offer novel perspectives on the prevention and management of cardiovascular diseases associated with hypertension. Additionally, the article outlines a total of 114 nonvolatile phytochemicals and 257 volatile components identified in A. venetum extract, which is a significant increase compared with the previous literature. Drawing upon published data, this paper also employs bioinformatic analysis to anticipate the potential activity of additional components. In conclusion, this article offers the most comprehensive summary to date of the traditional medicinal uses and components of A. venetum, serving as a scientific foundation for the potential expansion of its clinical application.
夹竹桃科罗布麻属植物罗布麻（Apocynum venetum L.），俗称“野麻”，在中国东部和东南亚地区被广泛用于医学。其最早的记载可追溯到东汉时期的《神农本草经》，书中将其称为“泽漆”。1977 年，罗布麻叶被正式列入《中国药典》。2020 年版《中国药典》赋予罗布麻叶多种功效，包括平肝安神、清热利水等。
尽管近年来对罗布麻叶的研究很多，但缺乏对最新研究结果的综合综述。本文的主要目的是通过对罗布麻叶的传统药用用途、植物化学和药理学机制进行深入分析，为研究人员提供更全面、更详细的参考。
本研究项目包括从 1957 年至 2024 年期间从各种数据库（包括 Web of Science、PubMed 和中国国家知识基础设施（CNKI））发表的原始文章。此外，还研究了古代中草药文本、博士论文和硕士论文中的数据，共涵盖 89 条记录。
罗布麻在传统民族医学中被广泛应用，其植物化学成分多样，含有 371 种化学成分，包括黄酮类、萜类、甾体、苯丙素类、有机酸、多糖和挥发油。尽管罗布麻的水溶性成分仍不完全清楚，但经验证据和学术文献表明，其提取物和化学成分具有多种有益的药理作用，特别是黄酮类化合物，具有心血管保护、抗癌、抗氧化和抗炎作用。
本文对罗布麻的传统和现代药用应用进行了全面综述。这些发现表明，罗布麻对治疗高血压有效，对高血脂、动脉粥样硬化和心肌损伤也有治疗作用。这一发现可能为高血压相关心血管疾病的预防和治疗提供新的思路。此外，本文共总结了 114 种非挥发性植物化学物质和 257 种罗布麻提取物中的挥发性成分，这一数字明显高于之前的文献。本文还利用已发表的数据，通过生物信息学分析预测了其他潜在成分的活性。总之，本文提供了迄今为止对罗布麻传统药用用途和成分最全面的总结，为其临床应用的潜在扩展提供了科学依据。
