运动能杀死肿瘤吗？
Can exercise kill tumors?
作者信息
Plaza-Florido Abel, Santos-Lozano Alejandro, Yanguas-Casás Natalia, Pinós Tomàs, Fiuza-Luces Carmen, Lucia Alejandro
机构信息
Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, Irvine, CA 92617, USA.
Department of Health Sciences, i+HeALTH, European University Miguel de Cervantes, Valladolid 47012, Spain.
出版信息
J Sport Health Sci. 2024 Oct 22;14:101001. doi: 10.1016/j.jshs.2024.101001.
Abstract
• A preventive effect of muscular activity against carcinomas was already postulated in the previous century. • The exercise milieu can help to improve anticancer immune function. • studies should be interpreted with caution because they do not recapitulate real-life (whole-body) scenarios. • Many questions remain open before we can claim that exercise “kills” tumors.
摘要
• 上世纪就已推测肌肉活动对癌症具有预防作用。
• 运动环境有助于提高抗癌免疫功能。
• 对这些研究的解读应谨慎，因为它们无法重现现实生活（全身）的情形。
• 在我们能够宣称运动“杀死”肿瘤之前，仍有许多问题悬而未决。
相似文献
1
Can exercise kill tumors?运动能杀死肿瘤吗？
J Sport Health Sci. 2024 Oct 22;14:101001. doi: 10.1016/j.jshs.2024.101001.
2
3
Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model.运动在小鼠黑色素瘤模型中促进促凋亡神经酰胺信号传导。
Cancers (Basel). 2022 Sep 2;14(17):4306. doi: 10.3390/cancers14174306.
4
Modification of alkylating agent induced cell kill by 2-nitroimidazoles in unclamped and clamped SC 9L tumors.2-硝基咪唑对未钳夹和钳夹的SC 9L肿瘤中烷化剂诱导的细胞杀伤作用的修饰
Int J Radiat Oncol Biol Phys. 1992;22(4):727-30. doi: 10.1016/0360-3016(92)90512-g.
5
Components of the human-specific, p53-mediated "kill switch" tumor suppression mechanism are usurped by human tumors, creating the possibility of therapeutic exploitation.人类特有的、由p53介导的“杀伤开关”肿瘤抑制机制的组成部分被人类肿瘤篡夺，从而产生了治疗利用的可能性。
Cancer Drug Resist. 2019 Dec 19;2(4):1207-1214. doi: 10.20517/cdr.2019.89. eCollection 2019.
6
Treatment of human prostate tumors PC-3 and TSU-PR1 with standard and investigational agents in SCID mice.在严重联合免疫缺陷（SCID）小鼠中用标准药物和研究性药物治疗人前列腺肿瘤PC-3和TSU-PR1。
Invest New Drugs. 1997;15(2):99-108. doi: 10.1023/a:1005856605726.
7
When exercise can kill: how to spot IHSS.运动何时会致命：如何识别肥厚型梗阻性心肌病。
RN. 1989 Sep;52(9):20-8.
8
Human umbilical cord blood NK T cells kill tumors by multiple cytotoxic mechanisms.人脐带血自然杀伤性T细胞通过多种细胞毒性机制杀伤肿瘤。
Hum Immunol. 2002 Mar;63(3):164-75. doi: 10.1016/s0198-8859(01)00382-2.
9
131-iodine conjugated antibody cell kill enhanced by bromodeoxyuridine.溴脱氧尿苷增强131碘共轭抗体细胞杀伤作用。
Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1437-40. doi: 10.1016/0360-3016(84)90364-x.
10
Acute Exercise Increases NK Cell Mitochondrial Respiration and Cytotoxicity against Triple-Negative Breast Cancer Cells under Hypoxic Conditions.急性运动增加 NK 细胞在缺氧条件下对三阴性乳腺癌细胞的线粒体呼吸和细胞毒性。
Med Sci Sports Exerc. 2023 Dec 1;55(12):2132-2142. doi: 10.1249/MSS.0000000000003250. Epub 2023 Jul 5.
引用本文的文献
1
History informing the future of exercise oncology.为运动肿瘤学的未来提供信息的历史。
J Natl Cancer Inst Monogr. 2025 Sep 1;2025(71):306-314. doi: 10.1093/jncimonographs/lgaf025.
本文引用的文献
1
Effects of short- and long-term exercise training on cancer cells in vitro: Insights into the mechanistic associations.短期和长期运动训练对体外癌细胞的影响：对机制关联的见解。
J Sport Health Sci. 2024 Oct 5;14:100994. doi: 10.1016/j.jshs.2024.100994.
2
Exercise and tumor proteome: insights from a neuroblastoma model.运动与肿瘤蛋白质组学：神经母细胞瘤模型的研究进展
Physiol Genomics. 2024 Dec 1;56(12):833-844. doi: 10.1152/physiolgenomics.00064.2024. Epub 2024 Sep 23.
3
Mechanisms and significance of entosis for tumour growth and progression.肿瘤细胞自噬在肿瘤生长和进展中的机制及意义
Cell Death Discov. 2024 Mar 1;10(1):109. doi: 10.1038/s41420-024-01877-9.
4
The effect of physical exercise on anticancer immunity.体育锻炼对抗癌免疫的影响。
Nat Rev Immunol. 2024 Apr;24(4):282-293. doi: 10.1038/s41577-023-00943-0. Epub 2023 Oct 4.
5
6
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer.运动诱导的 IL-15/IL-15Rα 轴激活促进胰腺癌中的抗肿瘤免疫。
Cancer Cell. 2022 Jul 11;40(7):720-737.e5. doi: 10.1016/j.ccell.2022.05.006. Epub 2022 Jun 2.
7
Exerkines in health, resilience and disease.运动因子在健康、适应力和疾病中的作用。
Nat Rev Endocrinol. 2022 May;18(5):273-289. doi: 10.1038/s41574-022-00641-2. Epub 2022 Mar 18.
8
Chronic inflammation in the etiology of disease across the life span.慢性炎症在整个生命周期疾病发病机制中的作用。
Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Epub 2019 Dec 5.
9
The genomic landscape of pediatric cancers: Implications for diagnosis and treatment.儿科癌症的基因组景观：对诊断和治疗的影响。
Science. 2019 Mar 15;363(6432):1170-1175. doi: 10.1126/science.aaw3535.
10
Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.卡那单抗抑制白细胞介素-1β对动脉粥样硬化患者肺癌发病的影响：一项随机、双盲、安慰剂对照试验的探索性结果。
Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016/S0140-6736(17)32247-X. Epub 2017 Aug 27.
Zotero 插件