Lille Neuroscience et Cognition, Degenerative and Vascular Cognitive Disorders Team, UMR-S 1172, INSERM, Lille F-59000, France.
Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
J Affect Disord. 2025 Jan 15;369:1136-1144. doi: 10.1016/j.jad.2024.10.099. Epub 2024 Oct 22.
Anxiety is frequent after stroke; however, little is known about its determinants. This study aims to assess the prevalence and correlates of post stroke anxiety (PSA) within 3-6 months following ischemic stroke.
Three cohort studies from the STROKOG consortium were involved. Demographic and clinical data were standardized. PSA and PSD were assessed using inventories. The criteria for post-stroke cognitive impairment (PSCI) were at least one cognitive domain impaired if applicable, or a Montreal Cognitive Assessment (MoCA) score. Descriptive analyses were conducted to ascertain the prevalence of anxiety. Comparisons between anxious and non-anxious patients in the total sample were made using χ and t-tests. A two-step individual participant data (IPD) meta-analysis was employed to identify factors associated with PSA.
584 patients were included. The total prevalence of PSA was 35 % (95%CI = [31.23;38.97]) and ranged from 27 % to 45 % across cohorts. In the total sample, there was a higher proportion of females in the anxiety group than the non-anxiety group (χ = 19.62; p < 0.001). Anxious patients had lower education, (χ = 6.59; p = 0.03), higher stroke severity (t = 2.77; p = 0.002), and higher rates of PSD (χ = 118.09; p < 0.001), and PSCI (χ = 23.81, p < 0.001). The analysis demonstrates that the odds of presenting with PSA is larger in patients with PSCI (OR = 1.84, 95%CI = [1.14; 2.91]).
Anxiety is frequent after stroke, especially in females, and is associated with depression and cognitive impairment.
中风后常出现焦虑；然而，其决定因素知之甚少。本研究旨在评估缺血性中风后 3-6 个月内中风后焦虑（PSA）的发生率及其相关因素。
本研究涉及 STROKOG 联盟的三个队列研究。对人口统计学和临床数据进行了标准化。使用量表评估 PSA 和 PSD。中风后认知障碍（PSCI）的标准为，如果适用，则至少一个认知域受损，或蒙特利尔认知评估（MoCA）评分。进行描述性分析以确定焦虑的发生率。在总样本中，比较焦虑患者和非焦虑患者，使用 χ 和 t 检验。采用两步个体参与者数据（IPD）荟萃分析，确定与 PSA 相关的因素。
共纳入 584 例患者。PSA 的总发生率为 35%（95%CI=[31.23;38.97]），各队列间发生率为 27%-45%。在总样本中，焦虑组女性比例高于非焦虑组（χ=19.62;p<0.001）。焦虑患者的教育程度较低（χ=6.59;p=0.03），中风严重程度较高（t=2.77;p=0.002），抑郁（PSD）发生率较高（χ=118.09;p<0.001），以及认知障碍（PSCI）发生率较高（χ=23.81;p<0.001）。分析表明，存在 PSCI 的患者发生 PSA 的几率更大（OR=1.84，95%CI=[1.14;2.91]）。
中风后焦虑很常见，尤其是女性，且与抑郁和认知障碍有关。
