• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿托品或格隆溴铵与5毫克新斯的明：一项比较剂量反应研究。

Atropine or glycopyrrolate with neostigmine 5 mg: a comparative dose-response study.

作者信息

Salem M G, Ahearn R S

出版信息

J R Soc Med. 1986 Jan;79(1):19-21. doi: 10.1177/014107688607900107.

DOI:10.1177/014107688607900107
PMID:3944815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1290140/
Abstract

One hundred and fifteen patients, separated into 4 groups, received neostigmine 5 mg with either atropine 1.2 mg or 1.8 mg, or glycopyrrolate 0.6 mg or 0.9 mg. Those receiving 0.9 mg glycopyrrolate had insignificant changes in heart rate in the immediate postreversal period. It is recommended that when glycopyrrolate is used with 5 mg neostigmine, the optimum dose is 0.9 mg.

摘要

115名患者被分成4组，分别接受新斯的明5毫克与阿托品1.2毫克或1.8毫克，或格隆溴铵0.6毫克或0.9毫克的治疗。接受0.9毫克格隆溴铵治疗的患者在逆转后即刻心率变化不明显。建议当格隆溴铵与5毫克新斯的明联用时，最佳剂量为0.9毫克。

相似文献

1
Atropine or glycopyrrolate with neostigmine 5 mg: a comparative dose-response study.阿托品或格隆溴铵与5毫克新斯的明：一项比较剂量反应研究。
J R Soc Med. 1986 Jan;79(1):19-21. doi: 10.1177/014107688607900107.
2
Reversal of neuromuscular blockade: dose determination studies with atropine and glycopyrrolate given before or in a mixture with neostigmine.神经肌肉阻滞的逆转：在新斯的明之前或与新斯的明混合使用时给予阿托品和格隆溴铵的剂量确定研究。
Anesth Analg. 1981 Aug;60(8):557-62.
3
Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture.用于拮抗神经肌肉阻滞的格隆溴铵-新斯的明合剂：与阿托品-新斯的明合剂的比较。
Br J Anaesth. 1977 Aug;49(8):825-9. doi: 10.1093/bja/49.8.825.
4
Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade.分次剂量阿托品与格隆溴铵联合新斯的明用于逆转加拉明引起的神经肌肉阻滞的比较
Acta Anaesthesiol Scand. 1991 Jul;35(5):398-401. doi: 10.1111/j.1399-6576.1991.tb03317.x.
5
Effects of intravenous administration of glycopyrrolate and atropine in anaesthetised patients.静脉注射格隆溴铵和阿托品对麻醉患者的影响。
Anaesthesia. 1981 Mar;36(3):277-81. doi: 10.1111/j.1365-2044.1981.tb10200.x.
6
Glycopyrrolate as a substitute for atropine in neostigmine reversal of muscle relaxant drugs.格隆溴铵作为新斯的明拮抗肌松药时阿托品的替代药物。
Can Anaesth Soc J. 1972 Jul;19(4):399-411. doi: 10.1007/BF03005964.
7
Advantages of glycopyrrolate over atropine during reversal of pancuronium block.
Acta Anaesthesiol Scand. 1982 Apr;26(2):147-50. doi: 10.1111/j.1399-6576.1982.tb01743.x.
8
Comparison between glycopyrrolate and atropine in a mixture with neostigmine for reversal of neuromuscular blockade. Studies in patients following open heart surgery.格隆溴铵与阿托品分别与新斯的明混合用于逆转神经肌肉阻滞的比较。对心脏直视手术后患者的研究。
Br J Anaesth. 1985 Feb;57(2):184-7. doi: 10.1093/bja/57.2.184.
9
Comparison of Glycopyrrolate, atropine and hyoscine in mixture with neostigmine for reversal of neuromuscular block following closed mitral valvotomy.格隆溴铵、阿托品和东莨菪碱与新斯的明混合用于二尖瓣闭式切开术后神经肌肉阻滞逆转的比较。
Acta Anaesthesiol Scand. 1980 Aug;24(4):331-5. doi: 10.1111/j.1399-6576.1980.tb01558.x.
10
Glycopyrrolate: pharmacology and clinical use.格隆溴铵：药理学与临床应用
Anaesthesia. 1983 Dec;38(12):1195-204. doi: 10.1111/j.1365-2044.1983.tb12525.x.

引用本文的文献

1
The effect of glycopyrrolate vs. atropine in combination with neostigmine on cardiovascular system for reversal of residual neuromuscular blockade in the elderly: a randomized controlled trial.格隆溴铵与阿托品联合新斯的明对老年患者逆转残余神经肌肉阻滞对心血管系统的影响：一项随机对照试验。
BMC Anesthesiol. 2024 Apr 1;24(1):123. doi: 10.1186/s12871-024-02512-x.
2
Prevalence, risk factors, and optimized management of moderate-to-severe thirst in the post-anesthesia care unit.麻醉后护理单元中中重度口渴的患病率、风险因素和优化管理。
Sci Rep. 2020 Sep 30;10(1):16183. doi: 10.1038/s41598-020-73235-5.

本文引用的文献

1
PREVENTION AND TREATMENT OF d-TUBOCURARINE POISONING.
Science. 1944 Nov 24;100(2604):474-5. doi: 10.1126/science.100.2604.474.
2
Comparison of the effects of atropine and glycopyrrolate on various end-organs.阿托品与格隆溴铵对各终末器官作用的比较。
J R Soc Med. 1980 Oct;73(10):727-30.
3
Reversal of neuromuscular blockade: dose determination studies with atropine and glycopyrrolate given before or in a mixture with neostigmine.神经肌肉阻滞的逆转：在新斯的明之前或与新斯的明混合使用时给予阿托品和格隆溴铵的剂量确定研究。
Anesth Analg. 1981 Aug;60(8):557-62.
4
Glycopyrrolate-neostigmine and atropine-neostigmine mixtures affect postanesthetic arousal times differently.格隆溴铵-新斯的明合剂与阿托品-新斯的明合剂对麻醉后苏醒时间的影响不同。
Anesth Analg. 1980 Jun;59(6):431-4.
5
A comparison of atropine and glycopyrrolate in anaesthetic practice.
Acta Anaesthesiol Scand. 1982 Dec;26(6):620-5. doi: 10.1111/j.1399-6576.1982.tb01827.x.
6
Glycopyrrolate: pharmacology and clinical use.格隆溴铵：药理学与临床应用
Anaesthesia. 1983 Dec;38(12):1195-204. doi: 10.1111/j.1365-2044.1983.tb12525.x.
7
Response to tubocurarine chloride and its reversal by neostigmine methylsulfate in man.
JAMA. 1968 Feb 19;203(8):541-4.
8
Duration of action of neostigmine in man.
Can Anaesth Soc J. 1976 Jan;23(1):80-4. doi: 10.1007/BF03004997.
9
Comparative penetration of glycopyrrolate and atropine across the blood--brain and placental barriers in anesthetized dogs.
Anesthesiology. 1978 May;48(5):339-44. doi: 10.1097/00000542-197805000-00007.
10
Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture.用于拮抗神经肌肉阻滞的格隆溴铵-新斯的明合剂：与阿托品-新斯的明合剂的比较。
Br J Anaesth. 1977 Aug;49(8):825-9. doi: 10.1093/bja/49.8.825.