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用于拮抗神经肌肉阻滞的格隆溴铵-新斯的明合剂：与阿托品-新斯的明合剂的比较。

Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture.

作者信息

Mirakhur R K, Dundee J W, Clarke R S

出版信息

Br J Anaesth. 1977 Aug;49(8):825-9. doi: 10.1093/bja/49.8.825.

DOI:10.1093/bja/49.8.825
PMID:329848
Abstract

Glycopyrrolate, a new anticholinergic agent, was evaluated and compared with atropine. Glycopyrrolate 0.2 mg to neostigmine 1.0 mg was found to be safe and effective. The heart rates remained more stable with glycopyrrolate, and the frequency of arrhythmia, which was both transient and of no consequence, was similar in the two groups. The antisialogogue action of glycopyrrolate was superior to that of atropine.

摘要

格隆溴铵是一种新型抗胆碱能药物，对其进行了评估并与阿托品作比较。结果发现，0.2毫克格隆溴铵与1.0毫克新斯的明联用安全有效。使用格隆溴铵时心率保持更稳定，两组的心律失常发生率相似，均为短暂性且无严重后果。格隆溴铵的抑制唾液分泌作用优于阿托品。

相似文献

1
Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture.用于拮抗神经肌肉阻滞的格隆溴铵-新斯的明合剂：与阿托品-新斯的明合剂的比较。
Br J Anaesth. 1977 Aug;49(8):825-9. doi: 10.1093/bja/49.8.825.
2
Comparison of Glycopyrrolate, atropine and hyoscine in mixture with neostigmine for reversal of neuromuscular block following closed mitral valvotomy.格隆溴铵、阿托品和东莨菪碱与新斯的明混合用于二尖瓣闭式切开术后神经肌肉阻滞逆转的比较。
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Antagonism of neuromuscular block in the elderly. A comparison of atropine and glycopyrronium in a mixture with neostigmine.老年人神经肌肉阻滞的拮抗作用。阿托品与格隆溴铵与新斯的明混合使用的比较。
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Evaluation of glycopyrrolate and atropine as adjuncts to reversal of non-depolarizing neuromuscular blocking agents in a "true-to-life" situation.
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A comparison of glycopyrrolate and atropine during reversal of nondepolarizing neuromuscular block with neostigmine.新斯的明逆转非去极化神经肌肉阻滞过程中格隆溴铵与阿托品的比较。
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Comparison between glycopyrrolate and atropine in a mixture with neostigmine for reversal of neuromuscular blockade. Studies in patients following open heart surgery.格隆溴铵与阿托品分别与新斯的明混合用于逆转神经肌肉阻滞的比较。对心脏直视手术后患者的研究。
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引用本文的文献

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The effect of glycopyrrolate vs. atropine in combination with neostigmine on cardiovascular system for reversal of residual neuromuscular blockade in the elderly: a randomized controlled trial.格隆溴铵与阿托品联合新斯的明对老年患者逆转残余神经肌肉阻滞对心血管系统的影响：一项随机对照试验。
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Cholinergic enhancement reduces functional connectivity and BOLD variability in visual extrastriate cortex during selective attention.胆碱能增强可减少选择性注意时视觉外纹状皮层的功能连接和 BOLD 变异性。
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Selective effects of cholinergic modulation on task performance during selective attention.
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Neuropsychopharmacology. 2008 Mar;33(4):913-23. doi: 10.1038/sj.npp.1301461. Epub 2007 May 30.
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Pharm Res. 2003 Oct;20(10):1681-9. doi: 10.1023/a:1026160023030.
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Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory.胆碱能刺激会改变工作记忆过程中的表现及特定任务的局部脑血流量。
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Can J Anaesth. 1996 Jul;43(7):731-40. doi: 10.1007/BF03017959.
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J R Soc Med. 1980 Oct;73(10):727-30.
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