Kuźbicka Karolina, Pawłowska Iga, Kocić Ivan
Department of Pharmacology, Medical University of Gdańsk, Dębowa 23, 80-204, Gdańsk, Poland.
Int J Obes (Lond). 2025 Mar;49(3):478-491. doi: 10.1038/s41366-024-01662-9. Epub 2024 Oct 24.
Body weight gain is a prevalent adverse effect observed in psychiatric medication therapy. With the notable increase in mental health diagnoses among children and adolescents over the last decade, exacerbated by the COVID-19 pandemic, the use of medications associated with weight gain poses an additional risk for obesity development. This study aimed to identify psychiatric drugs that may induce weight gain in children as a side effect. Twenty-nine publications were included in this systematic review, investigating the effects of nineteen different drugs on children's weight. The majority of these drugs belonged to atypical antipsychotics and anticonvulsants. Nearly all included articles reported that the examined substances resulted in weight gain in children. As childhood obesity has become a significant problem with various metabolic, psychological and social consequences, it is crucial to carefully consider therapy options. In addition to evaluating effectiveness, it is important to also assess the potential for weight gain. Clinicians and nutrition specialists should individually evaluate patients' nutritional needs, evaluate obesity risk, and provide appropriate dietary guidance to minimalize the risk of weight gain.
体重增加是精神科药物治疗中常见的不良反应。在过去十年中,儿童和青少年心理健康诊断显著增加,新冠疫情更是加剧了这一情况,使用与体重增加相关的药物会给肥胖症的发展带来额外风险。本研究旨在确定可能导致儿童体重增加的精神科药物副作用。本系统评价纳入了29篇出版物,研究了19种不同药物对儿童体重的影响。这些药物大多属于非典型抗精神病药和抗惊厥药。几乎所有纳入的文章都报告称,所检测的物质会导致儿童体重增加。由于儿童肥胖已成为一个具有各种代谢、心理和社会后果的重大问题,因此仔细考虑治疗方案至关重要。除了评估有效性外,评估体重增加的可能性也很重要。临床医生和营养专家应分别评估患者的营养需求,评估肥胖风险,并提供适当的饮食指导,以尽量降低体重增加的风险。