Rostampour Kimia, Alipour Kimia, Mirjalili Fatemeh, Forootani Bita, Yekrang Safakar Hooman, Beigrezaei Sara, Forbes Scott C, Salehi-Abargouei Amin
Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nutr Cancer. 2025;77(2):164-178. doi: 10.1080/01635581.2024.2417457. Epub 2024 Oct 24.
Individual observational studies examining the association between polyphenols and the risk of lung cancer have reported mixed findings. Therefore, we performed a systematic review and meta-analysis to determine the pooled effects between polyphenol intake and lung cancer risk. A systematic search was performed on PubMed, Scopus, and Web of Science databases in April 2023. Random-effect models were used to estimate odd ratios (OR) and 95% confidence intervals (95% CI). In total, 20 studies were included in the systematic review. The pooled analyses indicated that a higher intake of flavonoids (OR = 0.81; 95% CI: 0.67,0.98; = 0.03) and isoflavone (OR = 0.82; 95% CI: 0.74,0.92; < 0.001) were associated with lower odds of lung cancer. In addition, the ingestion of anthocyanidin (OR = 0.80; 95% CI: 0.65,0.98; = 0.04), kaempferol (OR = 0.78; 95% CI: 0.64,0.96; = 0.02), quercetin (OR = 0.66; 95% CI: 0.48,0.91; = 0.01) and flavanones (OR = 0.71; 95% CI: 0.59,0.85; < 0.001) reduced the likelihood of developing lung cancer. Overall, our findings suggest that flavonoids, isoflavones, anthocyanidin, kaempferol, quercetin, and flavanones may protect against lung cancer.
个别观察性研究探讨了多酚与肺癌风险之间的关联，结果不一。因此，我们进行了一项系统评价和荟萃分析，以确定多酚摄入量与肺癌风险之间的综合效应。2023年4月，我们在PubMed、Scopus和Web of Science数据库中进行了系统检索。采用随机效应模型估计比值比（OR）和95%置信区间（95%CI）。系统评价共纳入20项研究。汇总分析表明，较高的黄酮类化合物摄入量（OR = 0.81；95%CI：0.67，0.98；P = 0.03）和异黄酮摄入量（OR = 0.82；95%CI：0.74，0.92；P < 0.001）与较低的肺癌发病几率相关。此外，摄入花青素（OR = 0.80；95%CI：0.65，0.98；P = 0.04）、山奈酚（OR = 0.78；95%CI：0.64，0.96；P = 0.02）、槲皮素（OR = 0.66；95%CI：0.48，0.91；P = 0.01）和黄烷酮（OR = 0.71；95%CI：0.59，0.85；P < 0.001）可降低患肺癌的可能性。总体而言，我们的研究结果表明，黄酮类化合物、异黄酮、花青素、山奈酚、槲皮素和黄烷酮可能预防肺癌。
