Liu Xiaohe, Alharbi Amnah, Gibson Rachel, Rodriguez-Mateos Ana
Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Curr Opin Clin Nutr Metab Care. 2025 Jul 1;28(4):316-322. doi: 10.1097/MCO.0000000000001132. Epub 2025 Apr 28.
(Poly)phenols are bioactive compounds in plant-based foods with well documented health benefits. Their metabolism in dependent on gut microbiota composition, diversity, and function, which modulate their bioavailability and physiological effects. This review examines recent insights into (poly)phenol-gut microbiota interactions, emphasizing their relevance in mediating health benefits and mechanisms of action.
Recent studies have identified a high interindividual variability in (poly)phenol metabolism, explored microbial-derived metabolites with potential health benefits, and revealed bidirectional influences between (poly)phenols and gut microbiota composition. Advances in analytical techniques and large-scale studies have refined our understanding of these interactions, but inconsistencies remain in linking specific microbial signatures to health outcomes.
Standardized methodologies and long-term studies are needed to clarify the impact of (poly)phenol-derived metabolites on human health. Future research should focus on personalized and targeted nutrition approaches to optimize (poly)phenol benefits.
（多）酚类是植物性食物中的生物活性化合物，其对健康有益，这一点已有充分记录。它们的代谢取决于肠道微生物群的组成、多样性和功能，而这些因素会调节其生物利用度和生理效应。本综述探讨了关于（多）酚类与肠道微生物群相互作用的最新见解，强调了它们在介导健康益处和作用机制方面的相关性。
最近的研究已经确定了（多）酚类代谢存在高度的个体间差异，探索了具有潜在健康益处的微生物衍生代谢物，并揭示了（多）酚类与肠道微生物群组成之间的双向影响。分析技术的进步和大规模研究深化了我们对这些相互作用的理解，但在将特定的微生物特征与健康结果联系起来方面仍存在不一致之处。
需要标准化的方法和长期研究来阐明（多）酚类衍生代谢物对人类健康的影响。未来的研究应侧重于个性化和有针对性的营养方法，以优化（多）酚类的益处。
