来自Led-Fertyl研究的健康与不健康饮食模式及精子质量

Healthy and unhealthy dietary patterns and sperm quality from the Led-Fertyl study.

作者信息

Davila-Cordova Estefanía, Salas-Huetos Albert, Valle-Hita Cristina, Fernández de la Puente María, Martínez María Ángeles, Palau-Galindo Antoni, Del Egido-González Claudia, Manzanares-Errazu José María, Sánchez-Resino Elena, Salas-Salvadó Jordi, Babio Nancy

机构信息

Universitat Rovira i Virgili, Unitat de Nutrició Humana. Departament de Bioquímica i Biotecnologia. Alimentació, Nutrició, Desenvolupament i Salut Mental ANUT-DSM, Reus, Spain.

Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.

出版信息

Andrology. 2024 Oct 24. doi: 10.1111/andr.13789.

DOI:10.1111/andr.13789

PMID:39449282

Abstract

BACKGROUND

Dietary patterns may affect sperm quality, but the scientific evidence is limited.

OBJECTIVE

To evaluate the association between adherence to different a-priori dietary patterns and sperm quality parameters in healthy reproductive-age men.

MATERIALS AND METHODS

A cross-sectional analysis was conducted using data from 200 young men enrolled in the Led-Fertyl study. Tertiles of six a-priori dietary patterns were estimated: four healthy dietary patterns [Mediterranean Diet Adherence Screener (MEDAS), Dietary Approaches to Stop Hypertension (DASH), Healthful Plant-Based Diet Index (hPDI) and EAT-Lancet Score], and two unhealthy dietary patterns [Western Diet and Unhealthful Plant-Based Diet Index (uPDI)]. Sperm quality parameters (count, concentration, vitality, total and progressive motility, and normal morphology) were considered the main outcomes.

RESULTS

Compared with the lowest tertile, participants in the highest MEDAS tertile had higher total sperm count (β = 3.2;95%CI: 1.0, 5.5) and concentration (β = 1.8;95%CI: 0.6, 3.0), and total (β = 8.2;95%CI: 1.3, 15.1) and progressive motility (β = 7.1;95%CI: 0.2, 14.0). Similarly, participants in the highest hPDI tertile had higher total sperm count (β = 3.4;95%CI: 1.4, 5.5) and concentration (β = 1.2;95%CI: 0.0, 2.3) compared with those in the lowest tertile. When these dietary patterns were modelled as continuous variables (for each 1-point increment in the specific score), an inverse association was found between the uPDI and Western and total sperm count [(β = -2.7;95%CI: -4.8, -0.7) and (β = -3.8;95%CI: -5.8, -1.7), respectively] and sperm concentration [(β = -1.2;95%CI: -2.4, -0.1) and (β = -1.7;95%CI: -2.8, -0.5), respectively]. Compared with participants in the lowest tertile, those in the highest uPDI tertile presented higher odds of abnormal sperm concentration (OR: 4.6;95%CI: 1.0, 19.9) and one or more seminogram abnormalities (OR: 2.3;95%CI: 1.1, 5.0).

CONCLUSIONS

Our findings suggest that higher adherence to healthy dietary patterns (Mediterranean and healthful plant-based diet) was positively associated with better sperm quality parameters, in contrast, greater adherence to unhealthy dietary patterns was inversely associated.

摘要

背景

饮食模式可能会影响精子质量，但科学证据有限。

目的

评估健康育龄男性对不同先验饮食模式的依从性与精子质量参数之间的关联。

材料与方法

使用参与Led-Fertyl研究的200名年轻男性的数据进行横断面分析。估计了六种先验饮食模式的三分位数：四种健康饮食模式[地中海饮食依从性筛查量表（MEDAS）、终止高血压饮食方法（DASH）、健康植物性饮食指数（hPDI）和《柳叶刀》饮食评分]，以及两种不健康饮食模式[西方饮食和不健康植物性饮食指数（uPDI）]。精子质量参数（计数、浓度、活力、总活力和前向运动能力以及正常形态）被视为主要结果。

结果

与最低三分位数相比，MEDAS最高三分位数的参与者总精子计数（β = 3.2；95%置信区间：1.0，5.5）和浓度（β = 1.8；95%置信区间：0.6，3.0）更高，总活力（β = 8.2；95%置信区间：1.3，15.1）和前向运动能力（β = 7.1；95%置信区间：0.2，14.0）也更高。同样，与最低三分位数的参与者相比，hPDI最高三分位数的参与者总精子计数（β = 3.4；95%置信区间：1.4，5.5）和浓度（β = 1.2；95%置信区间：0.0，2.3）更高。当将这些饮食模式建模为连续变量（特定评分每增加1分）时，发现uPDI与西方饮食模式和总精子计数呈负相关[分别为（β = -2.7；95%置信区间：-4.8，-0.7）和（β = -3.8；95%置信区间：-5.8，-1.7）]，与精子浓度也呈负相关[分别为（β = -1.2；95%置信区间：-2.4，-0.1）和（β = -1.7；95%置信区间：-2.8，-0.5）]。与最低三分位数的参与者相比，uPDI最高三分位数的参与者精子浓度异常的几率更高（比值比：4.6；95%置信区间：1.0，19.9），以及出现一项或多项精液分析异常的几率更高（比值比：2.3；95%置信区间：1.1，5.0）。