Taniguchi Kohei, Goto Keisuke, Yabushita Hiroki, Yamasaki Rie, Ichimura Koichi
Department of Pathology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan.
J Cutan Pathol. 2023 Nov;50(11):1006-1013. doi: 10.1111/cup.14523. Epub 2023 Aug 30.
Transcriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors.
TRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues.
The normal epidermis was TRPS1-. In contrast, the eccrine apparatus, epithelial compartment of the hair follicles, hair papilla, sebaceous glands, and anogenital mammary-like glands were TRPS1+. In primary cutaneous tumors, TRPS1 positivity varied in poroma (2/3), nodular hidradenoma (4/5), spiradenoma (4/4), cutaneous mixed tumor (5/5), trichilemmal cyst (7/8), proliferating trichilemmal tumor (1/3), pilomatricoma (9/9), sebaceoma (2/5), extramammary Paget disease (13/13), sebaceous carcinoma (2/2), actinic keratosis (3/10), Bowen disease (7/12), and squamous cell carcinoma (1/5) cases. All cases of seborrheic keratosis, basal cell carcinoma, Merkel cell carcinoma, and malignant melanoma were TRPS1-. All metastatic breast carcinoma cases (8/8) were highly positive for TRPS1, while all but one of the other metastatic tumor cases were TRPS1-.
TRPS1 immunoexpression was observed in several skin appendages and cutaneous tumors.
转录抑制因子GATA结合蛋白1（TRPS1）是一种转录因子，最近研究表明其在乳腺癌和肝癌的发生发展中发挥作用。在此，我们评估TRPS1在正常皮肤组织和各种皮肤肿瘤中的免疫表达情况。
对109例原发性皮肤肿瘤和19例转移性癌进行TRPS1免疫组化检测。同时也评估了TRPS1在正常皮肤组织中的表达。
正常表皮TRPS1呈阴性。相比之下，汗腺、毛囊上皮部分、毛乳头、皮脂腺以及肛周乳腺样腺体TRPS1呈阳性。在原发性皮肤肿瘤中，TRPS1阳性率在汗孔瘤（2/3）、结节状汗腺瘤（4/5）、螺旋腺瘤（4/4）、皮肤混合瘤（5/5）、毛发囊肿（7/8）、增生性毛发肿瘤（1/3）、毛母质瘤（9/9）、皮脂腺瘤（2/5）、乳腺外佩吉特病（13/13）、皮脂腺癌（2/2）、光化性角化病（3/10）、鲍温病（7/12）和鳞状细胞癌（1/5）病例中有所不同。所有脂溢性角化病、基底细胞癌、默克尔细胞癌和恶性黑色素瘤病例TRPS1均为阴性。所有转移性乳腺癌病例（8/8）TRPS1高度阳性，而其他转移性肿瘤病例除1例之外均为TRPS1阴性。
在几种皮肤附属器和皮肤肿瘤中观察到TRPS1免疫表达。
