Liang Qichen, Ma Huimin, Zhang Liming, Ning Lu, Zhao Yajun, Li Yang, He Baoyu, Yang Aiping, Zhang Ziteng
School of Clinical Medicine, Jining Medical University, Jining, Shandong 272000, PR China.
Departments of Thoracic Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, PR China.
Heliyon. 2024 Oct 5;10(20):e39030. doi: 10.1016/j.heliyon.2024.e39030. eCollection 2024 Oct 30.
An association between dietary habits and lung disease has been demonstrated in previous studies. Employing Mendelian randomization, we aimed to explore how different dietary intakes relate to pneumothorax, shedding light on the interplay among gut flora, the lung-gut axis, and pneumothorax.
Employing both two-sample and multi-sample Mendelian randomization (MR) analyses, we investigated 24 dietary intake variables to establish a strong association with pneumothorax. Causal inferences were drawn using the inverse variance weighted (IVW) method. To fortify our findings, we employed a diverse array of methodologies, including Weighted Median Estimator (WME), Weighted Mode, Simple Mode, Mendelian Randomization Pleiotropy Residual Sum and Outlier (MR-PRESSO), MR-Egger regression, and LASSO.
Our analysis identified genetic variants reliably predicting dietary intakes, meeting stringent criteria (p < 5 × 10) and demonstrating independence (r < 0.001). Causal-effect estimates derived from the IVW model unveiled a statistically significant association, indicating a causal correlation between pneumothorax and three dietary intakes. Specifically, heightened consumption of fresh fruit (OR = 0.196, 95%CI: 0.063-0.606, p = 0.004) and dried fruit (OR = 0.323, 95%CI: 0.114-0.911, p = 0.032) correlated with reduced pneumothorax risk, while increased processed meat intake (OR = 2.705, 95%CI: 1.026-7.128, p = 0.044) showed a positive correlation.
In summary, our MR analysis yields robust evidence supporting a causal correlation between dietary elements and pneumothorax. This study significantly advances our comprehension of pneumothorax risk factors, protective agents, and the intricate mechanisms of the lung-gut axis.
先前的研究已证明饮食习惯与肺部疾病之间存在关联。我们采用孟德尔随机化方法，旨在探究不同的饮食摄入量与气胸之间的关系，以阐明肠道菌群、肺-肠轴和气胸之间的相互作用。
我们采用双样本和多样本孟德尔随机化（MR）分析，研究了24个饮食摄入变量，以确定与气胸的强关联。使用逆方差加权（IVW）方法进行因果推断。为了加强我们的研究结果，我们采用了多种方法，包括加权中位数估计器（WME）、加权众数、简单众数、孟德尔随机化多效性残差和异常值（MR-PRESSO）、MR-Egger回归和套索回归。
我们的分析确定了可靠预测饮食摄入量的基因变异，符合严格标准（p < 5×10）并显示出独立性（r < 0.001）。IVW模型得出的因果效应估计显示出统计学上的显著关联，表明气胸与三种饮食摄入量之间存在因果关系。具体而言，新鲜水果（OR = 0.196，95%CI：0.063 - 0.606，p = 0.004）和干果（OR = 0.323，95%CI：0.114 - 0.911，p = 0.032）的摄入量增加与气胸风险降低相关，而加工肉类摄入量增加（OR = 2.705，95%CI：1.
