Meng Fan-Qiao, Zhang Yu, Bai Xiao-Xin, Kong Fan-Li, Li Feng-E
Department of Postgraduate, School of Clinical Medicine, Beihua University, Jilin, China.
Department of Pediatrics, The First Hospital of Jilin University, Changchun, China.
Front Neurol. 2024 Oct 9;15:1427692. doi: 10.3389/fneur.2024.1427692. eCollection 2024.
We investigated the potential relationship between age-related conditions, particularly sarcopenia and ischemic stroke (IS), through a two-sample Mendelian randomization (MR) study.
We conducted a two-sample bidirectional MR study to investigate the relationship between sarcopenia and stroke. Genetic instruments for sarcopenia were derived from the UK Biobank, while data on IS and its subtypes were obtained from the MEGASTROKE consortium. Inverse variance weighting (IVW) served as the primary analytical method. Additionally, heterogeneity and pleiotropy were assessed to ensure the robustness of the findings.
The analysis indicates a negative correlation between appendicular lean mass (ALM) and small vessel stroke (SVS; OR = 0.790, 95% CI: 0.703-0.888, < 0.001), a positive correlation with cardioembolic stroke (CES; OR = 1.165, 95% CI: 1.058-1.284, = 0.002), and no causal relationship with any ischemic stroke (AIS) or large artery stroke (LAS). Additionally, SVS is negatively associated with right-hand grip strength (OR = 0.639, 95% CI: 0.437-0.934, = 0.021), while AIS, LAS, and CES do not exhibit a causal relationship with grip strength. Furthermore, no causal relationship was identified between left-hand grip strength, usual walking pace, and IS or its subtypes. MR analysis reveals only a negative association between CES and usual walking pace (OR = 0.989, 95% CI: 0.980-0.998, = 0.013), with no associations found between other IS subtypes and sarcopenia-related traits.
This study demonstrates that a reduction in ALM and right-hand grip strength is associated with SVS, whereas decreased ALM may serve as a protective factor against CES. Conversely, our analysis suggests that CES can impact walking speed. Overall, these findings provide valuable insights into the prevention and treatment of these conditions.
我们通过一项两样本孟德尔随机化（MR）研究，调查了与年龄相关的状况，特别是肌肉减少症与缺血性中风（IS）之间的潜在关系。
我们进行了一项两样本双向MR研究，以调查肌肉减少症与中风之间的关系。肌肉减少症的遗传工具来自英国生物银行，而IS及其亚型的数据则从MEGASTROKE联盟获得。逆方差加权（IVW）作为主要分析方法。此外，还评估了异质性和多效性，以确保研究结果的稳健性。
分析表明，四肢瘦体重（ALM）与小血管性中风（SVS；比值比[OR]=0.790，95%置信区间[CI]：0.703-0.888，P<0.001）呈负相关，与心源性栓塞性中风（CES；OR=1.165，95%CI：1.058-1.284，P=0.002）呈正相关，与任何缺血性中风（AIS）或大动脉性中风（LAS）无因果关系。此外，SVS与右手握力呈负相关（OR=0.639，95%CI：0.437-0.934，P=0.021），而AIS、LAS和CES与握力无因果关系。此外，左手握力、通常步行速度与IS或其亚型之间未发现因果关系。MR分析仅显示CES与通常步行速度之间呈负相关（OR=0.989，95%CI：0.980-0.998，P=0.013），其他IS亚型与肌肉减少症相关特征之间未发现相关性。
本研究表明，ALM和右手握力降低与SVS相关，而ALM降低可能是CES的保护因素。相反，我们的分析表明，CES会影响步行速度。总体而言，这些发现为这些疾病的预防和治疗提供了有价值的见解。
