Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Int J Mol Sci. 2023 Oct 23;24(20):15483. doi: 10.3390/ijms242015483.
Oral inflammatory diseases (OIDs) include many common diseases such as periodontitis and pulpitis. The causes of OIDs consist microorganism, trauma, occlusal factors, autoimmune dis-eases and radiation therapy. When treated unproperly, such diseases not only affect oral health but also pose threat to people's overall health condition. Therefore, identifying OIDs at an early stage and exploring new therapeutic strategies are important tasks for oral-related research. Mitochondria are crucial organelles for many cellular activities and disruptions of mitochondrial function not only affect cellular metabolism but also indirectly influence people's health and life span. Mitochondrial dysfunction has been implicated in many common polygenic diseases, including cardiovascular and neurodegenerative diseases. Recently, increasing evidence suggests that mitochondrial dysfunction plays a critical role in the development and progression of OIDs and its associated systemic diseases. In this review, we elucidated the critical insights into mitochondrial dysfunction and its involvement in the inflammatory responses in OIDs. We also summarized recent research progresses on the treatment of OIDs targeting mitochondrial dysfunction and discussed the underlying mechanisms.
口腔炎性疾病（OIDs）包括许多常见疾病，如牙周炎和牙髓炎。OIDs 的病因包括微生物、创伤、咬合因素、自身免疫性疾病和放射治疗。如果治疗不当，这些疾病不仅会影响口腔健康，还会威胁到人们的整体健康状况。因此，早期识别 OIDs 并探索新的治疗策略是口腔相关研究的重要任务。线粒体是许多细胞活动的关键细胞器，线粒体功能的破坏不仅影响细胞代谢，还会间接影响人们的健康和寿命。线粒体功能障碍与许多常见的多基因疾病有关，包括心血管疾病和神经退行性疾病。最近，越来越多的证据表明，线粒体功能障碍在 OIDs 及其相关系统性疾病的发展和进展中起着关键作用。在这篇综述中，我们阐述了线粒体功能障碍及其在 OIDs 炎症反应中的作用的关键见解。我们还总结了针对线粒体功能障碍治疗 OIDs 的最新研究进展，并讨论了潜在的机制。
