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周期性麻痹:病例系列及文献综述

Periodic Paralysis: A Case Series with a Literature Review.

作者信息

Al Hariri Bassem, Hassan Muad Abdi, Sharif Muhammad, Alsakaji Obada Adel, Hassan Yussuf Abdi, Khalid Muayad Kasim

机构信息

Department of Medicine, Hamad Medical Corporation, Doha, Qatar.

Weill Cornell Medical College-Qatar (WCM-Q), Doha, Qatar.

出版信息

Case Rep Neurol. 2024 Oct 2;16(1):274-280. doi: 10.1159/000541585. eCollection 2024 Jan-Dec.

Abstract

INTRODUCTION

Periodic paralysis is a condition that causes recurrent episodes of flaccid paralysis, and it can be primary or secondary. Hypokalemic periodic paralysis is the most common type of primary periodic paralysis, and it is inherited through autosomal dominant gene transmission. Males are affected three times more often than females, and the paralysis attacks usually occur at night after a period of vigorous exercise. It is crucial to exclude other diagnostic entities based on the nature of presentation, physical examination, and paraclinical studies. Thyrotoxic periodic paralysis is more prevalent in Asian or Hispanic males with thyrotoxicosis, where up to 10% of thyrotoxic patients may experience periodic paralysis.

CASE PRESENTATIONS

Here, we present 6 cases of patients who came to our care with varying degrees of muscle weakness, each showing interesting and diverse laboratory results.

CONCLUSION

In patient assessment, it is crucial to consider social and family history. Even without this information, awareness of potential diagnoses is vital. The cause should be carefully considered for possible simple treatments. Failing to recognize and address this condition promptly could lead to severe outcomes. Timely identification and intervention are essential for effective disease management and patient welfare.

摘要

引言

周期性瘫痪是一种导致反复发作弛缓性麻痹的病症,可分为原发性或继发性。低钾性周期性瘫痪是最常见的原发性周期性瘫痪类型,通过常染色体显性基因传递遗传。男性受影响的几率是女性的三倍,麻痹发作通常在剧烈运动一段时间后的夜间发生。根据临床表现、体格检查和辅助检查的性质排除其他诊断实体至关重要。甲状腺毒症性周期性瘫痪在患有甲状腺毒症的亚洲或西班牙裔男性中更为普遍,其中高达10%的甲状腺毒症患者可能会经历周期性瘫痪。

病例报告

在此,我们展示6例因不同程度肌肉无力前来就诊的患者病例,每例均呈现出有趣且多样的实验室检查结果。

结论

在患者评估中,考虑社会和家族史至关重要。即使没有这些信息,了解潜在诊断也至关重要。应仔细考虑病因以便进行可能的简单治疗。未能及时识别和处理这种病症可能导致严重后果。及时识别和干预对于有效的疾病管理和患者福祉至关重要。

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本文引用的文献

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Periodic paralysis.周期性瘫痪
Handb Clin Neurol. 2018;148:505-520. doi: 10.1016/B978-0-444-64076-5.00032-6.
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Periodic paralysis.周期性瘫痪
Adv Genet. 2008;63:3-23. doi: 10.1016/S0065-2660(08)01001-8.
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Thyroid function and periodic paralysis.甲状腺功能与周期性麻痹。
Am J Med. 1961 Feb;30:327-33. doi: 10.1016/0002-9343(61)90104-8.

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