Duray P H, Cuono C B, Madri J A
J Surg Oncol. 1986 Jan;31(1):21-5. doi: 10.1002/jso.2930310104.
Accidental extravasation of the widely used antineoplastic anthracycline doxorubicin (adriamycin) is capable of causing serious and on-going skin and soft tissue necrosis leading to loss of limb function. The only effective cure has been the complete surgical excision of drug-contaminated tissue. Surgical excisions preparatory to skin grafting have often underestimated the extent of drug infiltration into tissue. Using an experimental technique utilizing the drug's natural property of red fluorescence, we were able to effect complete surgical excision by rhodamine fluorescence microscopy in frozen sections of resected skin.
广泛使用的抗肿瘤蒽环类药物阿霉素（ Adriamycin ）意外外渗可导致严重且持续的皮肤和软组织坏死，进而导致肢体功能丧失。唯一有效的治疗方法是彻底手术切除受药物污染的组织。为植皮做准备的手术切除常常低估了药物在组织中的浸润范围。利用该药物的红色荧光天然特性的实验技术，我们能够通过罗丹明荧光显微镜在切除皮肤的冰冻切片中实现完全手术切除。
